Publications
Detailed Information
Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, H. W. | - |
dc.contributor.author | Shin, E. S. | - |
dc.contributor.author | Lee, J. E. | - |
dc.contributor.author | Kwon, H. S. | - |
dc.contributor.author | Chun, E. | - |
dc.contributor.author | Kim, S. S. | - |
dc.contributor.author | Chang, Y. S. | - |
dc.contributor.author | Kim, Y. K. | - |
dc.contributor.author | Min, K. U. | - |
dc.contributor.author | Kim, Y. Y. | - |
dc.contributor.author | Cho, S. H. | - |
dc.date.accessioned | 2009-12-24T10:02:38Z | - |
dc.date.available | 2009-12-24T10:02:38Z | - |
dc.date.issued | 2006-11-24 | - |
dc.identifier.citation | Thorax. 2007 Mar;62(3):265-9. Epub 2006 Nov 22. | en |
dc.identifier.issn | 0040-6376 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17121871 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22556 | - |
dc.description.abstract | BACKGROUND: Atopy is considered to be a complex genetic trait and does not follow a simple mendelian pattern of inheritance. It is now well recognised that gene-gene interactions are important in complex genetic disease. AIM: To analyse the influence of gene-gene interactions in the development of atopy. METHODS: A total of 2055 ethnically identical participants aged 10-18 years living in rural areas on Jeju Island, Korea, were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergens. Gene-gene interactions among 12 polymorphic loci were analysed in the seven candidate genes of atopy using the multidimensionality-reduction method. RESULTS: A significant interaction was found between V297I in the gene coding vascular endothelial growth factor receptor 2 (KDR) and -308G-->A in the gene coding tumour necrosis factor (TNF)alpha on the risk of atopy, with a cross-validation consistency of 10 out of 10 and a prediction error of 35.9% (p = 0.001). Conventional logistic regression also revealed significant interactions between KDR and TNF for atopy. Individuals with the variant allele of -308G-->A in TNF (GA or AA) and V297I in KDR (VI or II) had a significantly higher risk of atopy (OR 2.23; 95% CI 1.48 to 3.57). CONCLUSION: KDR and TNF may synergistically influence the development of atopy through gene-gene interaction in Korean children and adolescents. | en |
dc.language.iso | en | - |
dc.publisher | BMJ Publishing Group | en |
dc.subject | Adolescent | en |
dc.subject | Child | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Hypersensitivity, Immediate/epidemiology/*genetics | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Male | en |
dc.subject | Polymorphism, Single Nucleotide/*genetics | en |
dc.subject | Regression Analysis | en |
dc.subject | Vascular Endothelial Growth Factor Receptor-2/*genetics | en |
dc.title | Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박흥우 | - |
dc.contributor.AlternativeAuthor | 신은순 | - |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 권혁수 | - |
dc.contributor.AlternativeAuthor | 전은영 | - |
dc.contributor.AlternativeAuthor | 김선신 | - |
dc.contributor.AlternativeAuthor | 장윤석 | - |
dc.contributor.AlternativeAuthor | 김윤근 | - |
dc.contributor.AlternativeAuthor | 민경업 | - |
dc.contributor.AlternativeAuthor | 김유영 | - |
dc.contributor.AlternativeAuthor | 조상헌 | - |
dc.identifier.doi | 10.1136/thx.2006.065482 | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.