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Interleukin-18 promoter polymorphisms in patients with Behcet's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yun Jong | - |
dc.contributor.author | Kang, Seong Wook | - |
dc.contributor.author | Park, Jeong Jin | - |
dc.contributor.author | Bae, Young Deok | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Lee, Eun Bong | - |
dc.contributor.author | Song, Yeong Wook | - |
dc.date.accessioned | 2009-12-24T10:25:40Z | - |
dc.date.available | 2009-12-24T10:25:40Z | - |
dc.date.issued | 2006-10-24 | - |
dc.identifier.citation | Hum Immunol. 2006 Oct;67(10):812-8. Epub 2006 Aug 23. | en |
dc.identifier.issn | 0198-8859 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17055358 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22567 | - |
dc.description.abstract | Behcet's disease (BD) is an idiopathic systemic inflammatory disease and is considered to be a T helper 1 (Th1) type cytokine driven disorder. Moreover, levels of interleukin-18 (IL-18), a pivotal mediator of Th1 cytokine response, have been reported to be upregulated in BD. Therefore, we investigated the distribution of IL-18 promoter -607 C/A and -137 G/C polymorphisms in 103 BD patients (mean age 41.0 years; 48 male, 55 female) using allele-specific-polymerase chain reaction. As compared with healthy control subjects, BD patients had a significantly higher frequency of the -607 CC genotype (42.7% vs 23.3%, odds ratio [OR] = 2.455, 95% confidence interval [CI] = 1.350-4.461, p(c) = 0.021) and a higher frequency of the -607 C allele (60.7% vs 48.1%, OR = 1.668, 95% CI = 1.129-2.464, p = 0.0101). Haplotype analysis showed that BD patients had significantly less -607A/-137G haplotype (27.3% vs 44.2%, OR = 0.469, 95% CI = 0.268-0.820, p(c) = 0.032) and -607A/-137G haplotype homozygote (5.8% vs 20.4%, OR = 0.242, 95% CI = 0.096-0.612, p(c) = 0.014) than control subjects. In addition, the frequency of -607C/-137G haplotype homozygote was significantly higher in BD patients than control subjects (48.5% vs 20.4%, OR = 3.684, 95% CI = 1.997-6.791, p(c) = 0.0014). Although there were no associations between the polymorphisms and clinical manifestations or severity, patients with the -607 CC genotype or -607C/-137G haplotype homozygote showed significantly earlier symptom development (p = 0.034 by ANOVA; p = 0.009 by t-test, respectively) than those with other genotypes or diplotypes. These results suggest that the IL-18 promoter gene is a candidate susceptibility gene in BD patients. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Adolescent | en |
dc.subject | Aged | en |
dc.subject | Arthritis/etiology | en |
dc.subject | Behcet Syndrome/complications/*genetics/immunology | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Haplotypes | en |
dc.subject | Heterozygote | en |
dc.subject | Homozygote | en |
dc.subject | Humans | en |
dc.subject | Interleukin-18/*genetics/immunology | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Polymorphism, Single Nucleotide/*genetics | en |
dc.subject | Promoter Regions, Genetic/*genetics | en |
dc.subject | Uveitis/etiology | en |
dc.title | Interleukin-18 promoter polymorphisms in patients with Behcet's disease | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 이윤종 | - |
dc.contributor.AlternativeAuthor | 강승욱 | - |
dc.contributor.AlternativeAuthor | 박정진 | - |
dc.contributor.AlternativeAuthor | 배영덕 | - |
dc.contributor.AlternativeAuthor | 이영은 | - |
dc.contributor.AlternativeAuthor | 이은봉 | - |
dc.contributor.AlternativeAuthor | 송영욱 | - |
dc.identifier.doi | 10.1016/j.humimm.2006.07.012 | - |
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