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The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. R. | - |
dc.contributor.author | Cho, K. H. | - |
dc.date.accessioned | 2009-12-24T10:36:16Z | - |
dc.date.available | 2009-12-24T10:36:16Z | - |
dc.date.issued | 2006-11-23 | - |
dc.identifier.citation | Comput Biol Chem. 2006 Dec;30(6):438-44. Epub 2006 Nov 16. | en |
dc.identifier.issn | 1476-9271 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17112785 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22578 | - |
dc.description.abstract | E. coli has two-component systems composed of histidine kinase proteins and response regulator proteins. For a given extracellular stimulus, a histidine kinase senses the stimulus, autophosphorylates and then passes the phosphates to the cognate response regulators. The histidine kinase in an orthodox two-component system has only one histidine domain where the autophosphorylation occurs, but a histidine kinase in some unusual two-component systems (unorthodox two-component systems) has two histidine domains and one aspartate domain. So, the unorthodox two-component systems have more complex phosphorelay mechanisms than orthodox two-component systems. In general, the two-component systems are required to promptly respond to external stimuli for survival of E. coli. In this respect, the complex multi-step phosphorelay mechanism seems to be disadvantageous, but there are several unorthodox two-component systems in E. coli. In this paper, we investigate the reason why such unorthodox two-component systems are present in E. coli. For this purpose, we have developed simplified mathematical models of both orthodox and unorthodox two-component systems and analyzed their dynamical characteristics through extensive computer simulations. We have finally revealed that the unorthodox two-component systems realize ultrasensitive responses to external stimuli and also more robust responses to noises than the orthodox two-component systems. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | - |
dc.subject | Cell Survival | en |
dc.subject | Computer Simulation | en |
dc.subject | Escherichia coli/chemistry/*metabolism | en |
dc.subject | Escherichia coli Proteins/*metabolism | en |
dc.subject | Histidine/*metabolism | en |
dc.subject | Mathematics | en |
dc.subject | Phosphorylation | en |
dc.subject | Protein Kinases/*metabolism | en |
dc.subject | Noise | - |
dc.subject | Signal Transduction | - |
dc.title | The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김정래 | - |
dc.contributor.AlternativeAuthor | 조광현 | - |
dc.identifier.doi | 10.1016/j.compbiolchem.2006.09.004 | - |
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