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Regulation of IL-18 expression by CRH in mouse microglial cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Y. | - |
dc.contributor.author | Hahm, E. | - |
dc.contributor.author | Kim, Y. | - |
dc.contributor.author | Kang, J. | - |
dc.contributor.author | Lee, W. | - |
dc.contributor.author | Han, I. | - |
dc.contributor.author | Myung, P. | - |
dc.contributor.author | Kang, H. | - |
dc.contributor.author | Park, H. | - |
dc.contributor.author | Cho, D. | - |
dc.date.accessioned | 2009-12-24T11:12:47Z | - |
dc.date.available | 2009-12-24T11:12:47Z | - |
dc.date.issued | 2005-04-30 | - |
dc.identifier.citation | Immunol Lett. 2005 May 15;98(2):291-6. Epub 2004 Dec 30. | en |
dc.identifier.issn | 0165-2478 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15860230 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22602 | - |
dc.description.abstract | Corticotropin releasing hormone (CRH) is a major regulator of the stress response. This study examined whether CRH regulates interleukin-18 expression on microglia, BV2. Our data show that CRH enhanced IL-18 expression and significantly induced the secretion of functional IL-18 protein. Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18. Indeed, it was also found that CRH increased the generation of ROI. Taken together, these results indicate that CRH is an important mediator that regulates IL-18 expression in the brain during stress. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Animals | en |
dc.subject | Cells, Cultured | en |
dc.subject | Corticotropin-Releasing Hormone/*pharmacology | en |
dc.subject | Gene Expression Regulation/*drug effects | en |
dc.subject | Interferon-gamma/biosynthesis/secretion | en |
dc.subject | Interleukin-18/genetics/*metabolism | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Microglia/*drug effects/*metabolism | en |
dc.subject | RNA, Messenger/genetics | en |
dc.subject | Reactive Oxygen Species/metabolism | en |
dc.subject | Receptors, Corticotropin-Releasing Hormone/genetics | en |
dc.subject | Signal Transduction/drug effects | en |
dc.subject | Titrimetry | en |
dc.title | Regulation of IL-18 expression by CRH in mouse microglial cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 양율희 | - |
dc.contributor.AlternativeAuthor | 함은실 | - |
dc.contributor.AlternativeAuthor | 김영인 | - |
dc.contributor.AlternativeAuthor | 강재승 | - |
dc.contributor.AlternativeAuthor | 이왕재 | - |
dc.contributor.AlternativeAuthor | 한인옥 | - |
dc.contributor.AlternativeAuthor | 명평근 | - |
dc.contributor.AlternativeAuthor | 강형식 | - |
dc.contributor.AlternativeAuthor | 박현정 | - |
dc.contributor.AlternativeAuthor | 조대호 | - |
dc.identifier.doi | 10.1016/j.imlet.2004.12.003 | - |
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