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Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, J. H. | - |
dc.contributor.author | Kim, H. Y. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Chung, J. H. | - |
dc.contributor.author | Park, W. S. | - |
dc.contributor.author | Chung, D. H. | - |
dc.date.accessioned | 2009-12-24T11:25:06Z | - |
dc.date.available | 2009-12-24T11:25:06Z | - |
dc.date.issued | 2005-10-28 | - |
dc.identifier.citation | Am J Pathol. 2005 Nov;167(5):1231-41. | en |
dc.identifier.issn | 0002-9440 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16251408 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22624 | - |
dc.description.abstract | Pulmonary fibrosis is a progressive illness characterized by interstitial fibrosis. Although the precise mechanism for pulmonary fibrosis is not completely understood, an immune response involving interferon (IFN)-gamma appears to play a role. Therefore, we examined the functional roles of natural killer T (NKT) cells, which produce IFN-gamma and interleukin-4 on activation, in bleomycin-induced pulmonary fibrosis. In NKT cell-deficient mice, pulmonary fibrosis was worse in terms of histology, hydroxyproline levels, and mortality than in control mice. The transforming growth factor (TGF)-beta1 levels were higher in the lung after injecting bleomycin, and blockade of TGF-beta1 by neutralizing monoclonal antibody attenuated the pulmonary fibrosis in CD1d-/- mice. In contrast, the production of IFN-gamma was reduced in lungs from CD1d-/- mice. Moreover, the adoptive transfer of NKT cells into CD1d-/- mice increased IFN-gamma and reduced TGF-beta1 production, attenuating pulmonary fibrosis. An in vitro assay demonstrated that IFN-gamma was involved in suppressing TGF-beta1 production in cells collected from bronchoalveolar lavage. The adoptive transfer of NKT cells from IFN-gamma-/- mice did not reverse pulmonary fibrosis or TGF-beta1 production in lungs of CD1d-/- mice whereas NKT cells from B6 control mice attenuated fibrosis and reduced TGF-beta1 production. In conclusion, IFN-gamma-producing NKT cells play a novel anti-fibrotic role in pulmonary fibrosis by regulating TGF-beta1 production. | en |
dc.language.iso | en | en |
dc.publisher | American Society for Investigative Pathology (ASIP) | en |
dc.subject | Adoptive Transfer | en |
dc.subject | Animals | en |
dc.subject | Bleomycin | en |
dc.subject | Body Weight | en |
dc.subject | Cells, Cultured | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Hydroxyproline/analysis | en |
dc.subject | Interferon-gamma/*biosynthesis/genetics | en |
dc.subject | Killer Cells, Natural/*immunology | en |
dc.subject | Lung/drug effects/*pathology | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Mice, Knockout | en |
dc.subject | Pulmonary Fibrosis/chemically induced/*immunology/*pathology | en |
dc.subject | T-Lymphocyte Subsets/*immunology | en |
dc.subject | Transforming Growth Factor beta/metabolism | en |
dc.subject | Transforming Growth Factor beta1 | en |
dc.title | Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김지형 | - |
dc.contributor.AlternativeAuthor | 김혜영 | - |
dc.contributor.AlternativeAuthor | 김상희 | - |
dc.contributor.AlternativeAuthor | 정진행 | - |
dc.contributor.AlternativeAuthor | 박원서 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
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