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Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, H. H. | - |
dc.contributor.author | Shin, C. M. | - |
dc.contributor.author | Park, C. H. | - |
dc.contributor.author | Kim, K. H. | - |
dc.contributor.author | Cho, K. H. | - |
dc.date.accessioned | 2009-12-24T11:27:10Z | - |
dc.date.available | 2009-12-24T11:27:10Z | - |
dc.date.issued | 2005-06-03 | - |
dc.identifier.citation | J Lipid Res. 2005 Aug;46(8):1712-20. Epub 2005 Jun 1. | en |
dc.identifier.issn | 0022-2275 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15930517 | - |
dc.identifier.uri | https://hdl.handle.net/10371/22626 | - |
dc.description.abstract | Ultraviolet (UV) irradiation regulates UV-responsive genes, including matrix metalloproteinases (MMPs). Moreover, UV-induced MMPs cause connective tissue damage and the skin to become wrinkled and aged. Here, we investigated the effect of eicosapentaenoic acid (EPA), a dietary omega-3 fatty acid, on UV-induced MMP-1 expression in human dermal fibroblasts (HDFs). We found that UV radiation increases MMP-1 expression and that this is mediated by p44 and p42 MAP kinase (ERK) and Jun-N-terminal kinase (JNK) activation but not by p38 activation. Pretreatment of HDFs with EPA inhibited UV-induced MMP-1 expression in a dose-dependent manner and also inhibited the UV-induced activation of ERK and JNK by inhibiting ERK kinase (MEK1) and SAPK/ERK kinase 1 (SEK1) activation, respectively. Moreover, inhibition of ERK and JNK by EPA resulted in the decrease of c-Fos expression and c-Jun phosphorylation/expression induced by UV, respectively, which led to the inhibition of UV-induced activator protein-1 DNA binding activity. This inhibitory effect of EPA on MMP-1 was not mediated by an antioxidant effect. We also found that EPA inhibited 12-O-tetradecanoylphorbol-13-acetate- or tumor necrosis factor-alpha-induced MMP-1 expression in HDFs and UV-induced MMP-1 expression in HaCaT cells. In conclusion, our results demonstrate that EPA can inhibit UV-induced MMP-1 expression by inhibiting the MEK1/ERK/c-Fos and SEK1/JNK/c-Jun pathways. Therefore, EPA is a potential agent for the prevention and treatment of skin aging. | en |
dc.language.iso | en | en |
dc.publisher | American Society for Biochemistry and Molecular Biology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Eicosapentaenoic Acid/*pharmacology | en |
dc.subject | Fatty Acids, Omega-3/pharmacology | en |
dc.subject | Fibroblasts/*metabolism | en |
dc.subject | Gene Expression Regulation/drug effects/*radiation effects | en |
dc.subject | Humans | en |
dc.subject | JNK Mitogen-Activated Protein Kinases/metabolism | en |
dc.subject | Matrix Metalloproteinase 1/*genetics | en |
dc.subject | Mitogen-Activated Protein Kinase 1/metabolism | en |
dc.subject | Mitogen-Activated Protein Kinase 3/metabolism | en |
dc.subject | Signal Transduction | en |
dc.subject | Skin/cytology | en |
dc.subject | Ultraviolet Rays | - |
dc.title | Eicosapentaenoic acid inhibits UV-induced MMP-1 expression in human dermal fibroblasts | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김현호 | - |
dc.contributor.AlternativeAuthor | 신정민 | - |
dc.contributor.AlternativeAuthor | 박치현 | - |
dc.contributor.AlternativeAuthor | 김규한 | - |
dc.contributor.AlternativeAuthor | 조광현 | - |
dc.contributor.AlternativeAuthor | 은희철 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1194/jlr.M500105-JLR200 | - |
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