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Bronchoalveolar lavage eosinophil cationic protein and interleukin-8 levels in acute asthma and acute bronchiolitis

Cited 24 time in Web of Science Cited 25 time in Scopus
Authors
Kim, C. K.; Kim, S. W.; Kim, Y. K.; Kang, H.; Yu, J.; Yoo, Y.; Koh, Y. Y.
Issue Date
2005-05-19
Publisher
Wiley-Blackwell
Citation
Clin Exp Allergy. 2005 May;35(5):591-7.
Keywords
Acute DiseaseAsthma/*metabolismBronchiolitis/*metabolismBronchoalveolar Lavage Fluid/*chemistry/cytologyBronchoscopy/methodsChild, PreschoolEosinophil Cationic Protein/*analysisEosinophils/chemistryFemaleHumansInterleukin-8/*analysisMacrophages/chemistryMaleNeutrophils/chemistry
Abstract
OBJECTIVE: In this study, we measured the levels of eosinophil cationic protein (ECP) and interleukin (IL)-8 in bronchoalveolar lavage (BAL) fluid from patients with acute asthma and acute bronchiolitis, to determine any similarities or dissimilarities in the profiles of these biochemical markers in the two diseases. METHODS: BAL fluids were obtained from children with acute asthma (n=16), infants with acute bronchiolitis caused by respiratory syncytial virus (n=18), and control subjects (n=14). Children with asthma were selected to be free of viral infection. BAL cell counts and differentials were determined, and ECP and IL-8 levels were measured by radioimmunoassay and ELISA, respectively. RESULTS: ECP levels in BAL fluids were significantly higher in the asthma group than in the bronchiolitis (P<0.01) or control (P<0.0001) groups. However, IL-8 levels were significantly higher in the bronchiolitis group than in the asthma (P<0.01) or control (P<0.001) groups. IL-8 levels in the asthma group and ECP levels in the bronchiolitis group were similar to those of the control group. CONCLUSION: This difference in profiles of ECP and IL-8 in acute asthma and acute bronchiolitis, together with a different inflammatory cell pattern, suggests that the nature of the inflammatory process within the lower respiratory tract may be distinctive in these two diseases.
ISSN
0954-7894 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15898980

https://hdl.handle.net/10371/22627
DOI
https://doi.org/10.1111/j.1365-2222.2005.02224.x
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College of Medicine/School of Medicine (의과대학/대학원)Immunology (면역학전공)Journal Papers (저널논문_면역학전공)
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