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Clinical outcomes of childhood lupus nephritis: a single center's experience

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dc.contributor.authorLee, Byong Sop-
dc.contributor.authorCho, Hee Yeon-
dc.contributor.authorKim, Eo Jin-
dc.contributor.authorKang, Hee Gyung-
dc.contributor.authorHa, Il Soo-
dc.contributor.authorCheong, Hae Il-
dc.contributor.authorKim, Joong Gon-
dc.contributor.authorLee, Hyun Soon-
dc.contributor.authorChoi, Yong-
dc.date.accessioned2009-12-28T06:56:28Z-
dc.date.available2009-12-28T06:56:28Z-
dc.date.issued2006-11-30-
dc.identifier.citationPediatr Nephrol. 2007 Feb;22(2):222-31. Epub 2006 Nov 28.en
dc.identifier.issn0931-041X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17131162-
dc.identifier.urihttp://hdl.handle.net/10371/22854-
dc.description.abstractThis study retrospectively reviewed the medical records of children with lupus nephritis (LN) who were treated at Seoul National University Children's Hospital from 1986 to 2005 (mean duration 8.3+/-4.4 years). The records of 77 children (22 male and 55 female) were examined. The mean age at diagnosis was 11.9+/-3.0 years. The initial biopsy results revealed a WHO class IV classification for 60 (88.2%) of 68 biopsy proven cases. Of 77 patients, 67 (87.0%) responded initially to the high-dose corticosteroids with or without additional immunosuppressive therapy. Of the initial responders (67), 30 (44.8%) experienced at least one episode of proteinuric (24) or nephritic (6) flare. Thirteen patients (16.9%) progressed to either chronic renal failure (CRF) or end-stage renal disease (ESRD). Six (7.8%) patients died. A Kaplan-Meier estimate of patient survival and CRF-free survival rate was 95.4% and 88.7% at 5 years and 91.8% and 74.7% at 10 years, respectively. Multivariate analysis for class IV LN revealed male gender (P=0.029), initial hypertension (P=0.001) and absence of remission (P=0.002) to be prognostic factors predicting CRF. Glomerulosclerosis of 10% or more (P=0.005), nephritic flare (P=0.011), and presence of anti-phospholipid antibody (P=0.017) or syndrome (P=0.004) were also found to be independent risk factors for CRF. Cyclophosphamide pulse therapy failed to demonstrate superiority over other combined immunosuppressants used for the treatment of diffuse proliferative LN.en
dc.language.isoen-
dc.publisherSpringer Verlagen
dc.subjectAdolescenten
dc.subjectAntiphospholipid Syndrome/diagnosis/etiologyen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDisease Progressionen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImmunosuppressive Agents/therapeutic useen
dc.subjectKaplan-Meiers Estimateen
dc.subjectKidney Failure, Chronic/diagnosis/etiologyen
dc.subjectKoreaen
dc.subjectLupus Nephritis/*complications/*diagnosis/drug therapy/mortalityen
dc.subjectMaleen
dc.subjectPrognosisen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.subjectSurvival Rateen
dc.titleClinical outcomes of childhood lupus nephritis: a single center's experienceen
dc.typeArticleen
dc.contributor.AlternativeAuthor이병섭-
dc.contributor.AlternativeAuthor조희연-
dc.contributor.AlternativeAuthor김어진-
dc.contributor.AlternativeAuthor강희경-
dc.contributor.AlternativeAuthor하일수-
dc.contributor.AlternativeAuthor정해일-
dc.contributor.AlternativeAuthor김중곤-
dc.contributor.AlternativeAuthor이현순-
dc.contributor.AlternativeAuthor최용-
dc.identifier.doi10.1007/s00467-006-0286-0-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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