Browse

GSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational population

DC Field Value Language
dc.contributor.authorKim, Jin Hee-
dc.contributor.authorLee, Kwan-Hee-
dc.contributor.authorYoo, Dong Ho-
dc.contributor.authorKang, Daehee-
dc.contributor.authorCho, Soo-Hun-
dc.contributor.authorHong, Yun-Chul-
dc.date.accessioned2009-12-29-
dc.date.available2009-12-29-
dc.date.issued2007-02-15-
dc.identifier.citationMutat Res. 2007 Apr 20;629(1):32-9. Epub 2007 Jan 13.en
dc.identifier.issn0027-5107 (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2D-4MTC6NK-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a0837fd5084d8792b9082cd6345a9472-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17298885-
dc.identifier.urihttps://hdl.handle.net/10371/22898-
dc.description.abstractInflammation is known to be an important underlying condition in the development of a variety of diseases. To investigate whether blood lead induces inflammatory reactions in non-occupationally exposed adults and the effects of genetic susceptibility associated with GSTM1 and TNF-alpha gene polymorphisms on this inflammatory response, we measured blood lead levels in 300 healthy university students. Total serum TNF-alpha and IL-6 levels and WBC counts were determined to evaluate the inflammatory response. Allelic loss of GSTM1 and the TNF-alpha-308 G>A polymorphism were determined by PCR and RFLP. Positive relations between blood lead and three inflammation biomarkers were shown in male subjects with blood lead > or =2.51microg/dl (median value) (TNF-alpha, p=0.015; IL-6, p=0.082; and WBC, p=0.044). However, subgroup analysis by genotype showed an effect of blood lead on the three biomarkers only in individuals with the GSTM1 null (TNF-alpha, p=0.020; IL-6, p=0.096; and WBC, p=0.017) or TNF-alpha GG (TNF-alpha, p=0.017; IL-6, p=0.088; and WBC, p=0.095) genotype, and not in individuals with GSTM1 present (all three inflammatory biomarkers, p>0.1) or the TNF-alpha GA or AA (all three biomarkers, p>0.1) genotype. These results suggest that blood lead affects the inflammatory response and that GSTM1 and TNF-alpha gene polymorphisms are genetic factors associated with lead-induced inflammatory response.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectBiological Markers/blooden
dc.subjectEnzyme-Linked Immunosorbent Assayen
dc.subjectFemaleen
dc.subjectGlutathione Transferase/*geneticsen
dc.subjectHumansen
dc.subjectInflammation/*blooden
dc.subjectInterleukin-6/blooden
dc.subjectLead/*blooden
dc.subjectLeukocyte Counten
dc.subjectMaleen
dc.subjectPolymerase Chain Reactionen
dc.subjectPolymorphism, Restriction Fragment Lengthen
dc.subjectStudentsen
dc.subjectTumor Necrosis Factor-alpha/blood/*geneticsen
dc.subjectPolymorphism, Genetic-
dc.titleGSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational populationen
dc.typeArticleen
dc.contributor.AlternativeAuthor김진희-
dc.contributor.AlternativeAuthor이관희-
dc.contributor.AlternativeAuthor유동호-
dc.contributor.AlternativeAuthor강대희-
dc.contributor.AlternativeAuthor조수현-
dc.contributor.AlternativeAuthor홍윤철-
dc.identifier.doi10.1016/j.mrgentox.2007.01.004-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse