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Optic pathway glioma: outcome and prognostic factors in a surgical series

Cited 39 time in Web of Science Cited 40 time in Scopus
Authors
Ahn, Yong; Cho, Byung-Kyu; Kim, Seung-Ki; Chung, You-Nam; Lee, Chang Sub; Kim, Il Han; Yang, Sei Won; Kim, Hee-Soo; Kim, Hyun Jib; Jung, Hee-Won; Wang, Kyu-Chang
Issue Date
2006-04-22
Publisher
Springer Verlag
Citation
Childs Nerv Syst. 2006 Sep;22(9):1136-42. Epub 2006 Apr 21.
Keywords
AdolescentAge FactorsChildChild, PreschoolDisease ProgressionDisease-Free SurvivalDominance, Cerebral/physiologyFemaleHumansHypothalamic Neoplasms/pathology/surgeryInfantMaleNeurologic ExaminationOptic Chiasm/pathology/surgeryOptic Nerve Glioma/diagnosis/mortality/pathology/*surgeryPostoperative Complications/etiology/surgeryPrognosisReoperationRetrospective StudiesSex FactorsSurvival Rate
Abstract
OBJECTS: The goals of this study were to evaluate the surgical outcomes of optic pathway glioma (OPG) and to analyze the prognostic factors related to the progression-free survival. MATERIALS AND METHODS: A retrospective review was conducted on 33 patients who underwent surgery for OPG; these included 15 male and 18 female patients with a mean age of 8.3 years. The mean duration of follow-up was 52 months. RESULTS AND CONCLUSIONS: The preservation rate of ipsilateral vision was 25%, while that of contralateral vision was 83% (P<0.001). There was no remarkable endocrine improvement after surgery. The overall and progression-free survival rates at 5 years were 93.6 and 52.4%, respectively. In our study, the predictors for tumor progression were children younger than 5 years of age (p=0.023) and of female gender (p=0.022). Because of the variable course of OPG, treatment policy should be optimized individually according to patient's status.
ISSN
0256-7040 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16628460

http://hdl.handle.net/10371/22911
DOI
https://doi.org/10.1007/s00381-006-0086-7
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College of Medicine/School of Medicine (의과대학/대학원)Radiation Oncology (방사선종양학전공)Journal Papers (저널논문_방사선종양학전공)
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