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CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk
DC Field | Value | Language |
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dc.contributor.author | Han, Sohee | - |
dc.contributor.author | Lee, Kyoung-Mu | - |
dc.contributor.author | Choi, Ji-Yeob | - |
dc.contributor.author | Park, Sue Kyung | - |
dc.contributor.author | Lee, Ji-Young | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Noh, Dong-Young | - |
dc.contributor.author | Ahn, Sei-Hyun | - |
dc.contributor.author | Han, Wonshik | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Hong, Yun-Chul | - |
dc.contributor.author | Ha, Eunhee | - |
dc.contributor.author | Yoo, Keun-Young | - |
dc.contributor.author | Kang, Daehee | - |
dc.date.accessioned | 2009-12-29T07:01:36Z | - |
dc.date.available | 2009-12-29T07:01:36Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Breast Cancer Res Treat 110:387-393 | en |
dc.identifier.issn | 1573-7217 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17940865 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23144 | - |
dc.description.abstract | OBJECTIVES: This study was conducted to evaluate the potential role of CASP8 genetic polymorphisms in the etiology of breast cancer in a case-control study, Korea. METHODS: Incident breast cancer cases confirmed histologically (n = 1,599) were recruited from two hospitals in Seoul during 2001-2005. Control subjects (n = 1,536) were selected from the Health Examinee Cohort from Seoul and Gyeonggi Province surrounding Seoul, Korea. Three SNPs (D302H D > H, 5'-UTR C > T, and K337K G > A) were genotyped by the primer extension assay. The CASP8 D302H, which was not polymorphic in 48 samples, was excluded in further genotyping. Odds ratios and 95% confidential intervals (95% CIs) were estimated by unconditional logistic regression model adjusted for age at enrollment, education, age at first full-term pregnancy, cigarette smoking, and family history of breast cancer. RESULTS: The 5'-UTR T allele containing genotypes (CT/TT) were associated with an increased risk of breast cancer, compared with those with the CC genotype (OR = 1.13, 95% CI = 0.95-1.34; and OR = 1.48, 95% CI = 1.04-2.10, respectively; P-trend = 0.02). When stratified by the estrogen and progesterone receptor status, the association between the 5'-UTR T allele and breast cancer risk was prominent in ER(+) and PR(+) cases among pre-menopausal women (OR = 1.31, 95% CI = 1.00-1.72 and OR = 1.40, 95% CI = 1.06-1.85, respectively), whereas the association was found prominent in ER(-) or PR(-) cases (OR = 1.32, 95% CI = 0.93-1.87 and OR = 1.42, 95% CI = 1.04-1.94, respectively) among post-menopausal women. CONCLUSION: Our results thus suggest that the CASP8 5'-UTR C > T are associated with breast cancer risks and the effect may be modified by estrogen and progesterone receptor status. | en |
dc.description.sponsorship | This study
was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620410-1). | en |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | en |
dc.subject | 5' Untranslated Regions | en |
dc.subject | Adult | en |
dc.subject | Breast Neoplasms/ethnology/*genetics/metabolism | en |
dc.subject | Case-Control Studies | en |
dc.subject | Caspase 8/*genetics | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Korea | en |
dc.subject | Middle Aged | en |
dc.subject | Odds Ratio | en |
dc.subject | Receptors, Estrogen/*metabolism | en |
dc.subject | Receptors, Progesterone/*metabolism | en |
dc.subject | Risk | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | CASP8 polymorphisms, estrogen and progesterone receptor status, and breast cancer risk | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 한소희 | - |
dc.contributor.AlternativeAuthor | 이경무 | - |
dc.contributor.AlternativeAuthor | 최지엽 | - |
dc.contributor.AlternativeAuthor | 박수경 | - |
dc.contributor.AlternativeAuthor | 이지영 | - |
dc.contributor.AlternativeAuthor | 이종은 | - |
dc.contributor.AlternativeAuthor | 노동영 | - |
dc.contributor.AlternativeAuthor | 안세현 | - |
dc.contributor.AlternativeAuthor | 한원식 | - |
dc.contributor.AlternativeAuthor | 김동현 | - |
dc.contributor.AlternativeAuthor | 홍윤철 | - |
dc.contributor.AlternativeAuthor | 하은희 | - |
dc.contributor.AlternativeAuthor | 유근영 | - |
dc.contributor.AlternativeAuthor | 강대희 | - |
dc.identifier.doi | 10.1007/s10549-007-9730-5 | - |
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