Publications
Detailed Information
Angiotensin II type 1 receptor 1166A/C polymorphism in association with blood pressure response to exogenous angiotensin II
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Hyeong-Seok | - |
dc.contributor.author | Cho, Joo-Youn | - |
dc.contributor.author | Oh, Dal-Seok | - |
dc.contributor.author | Chung, Jae-Yong | - |
dc.contributor.author | Hong, Kyoung-Sup | - |
dc.contributor.author | Bae, Kyun-Seop | - |
dc.contributor.author | Yu, Kyung-Sang | - |
dc.contributor.author | Lee, Kyung-Hoon | - |
dc.contributor.author | Jang, In-Jin | - |
dc.contributor.author | Shin, Sang-Goo | - |
dc.date.accessioned | 2009-12-30 | - |
dc.date.available | 2009-12-30 | - |
dc.date.issued | 2006-12-06 | - |
dc.identifier.citation | Eur J Clin Pharmacol. 2007 Jan;63(1):17-26. Epub 2006 Dec 5. | en |
dc.identifier.issn | 0031-6970 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17146658 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23384 | - |
dc.description.abstract | BACKGROUND: The angiotensin II type 1 receptor (AT1R) 1166A/C polymorphism is reported to be implicated in cardiovascular diseases. The association between the 1166A/C polymorphism and diastolic blood pressure (DBP) changes in response to exogenous angiotensin II and valsartan was evaluated by pharmacokinetic and pharmacodynamic modeling. METHODS: Thirteen normotensive, healthy adults (six with the 1166A/A polymorphism and seven with 1166A/C) were enrolled in this clinical study. Angiotensin II was infused continuously over a 2-min period at four different rates (from 5 ng/kg/min and increased by 5 ng/kg/min) at 0 (before valsartan dosing), 2, 4, 8, 12, and 24 h after a single oral dose of valsartan (40 mg). BP was measured serially before and at the end of each rate of angiotensin II infusion. Plasma concentration-time profiles of valsartan were established over a 24-h period. We analyzed data using NONMEM and studied the relationship between the AT1R 1166A/C genotypes and BP responses. RESULTS: Plasma valsartan concentrations and DBP data best fitted into a two-compartment linear model and E(max) model (E(max) with baseline for angiotensin II and inhibitory E(max) for valsartan), respectively. The ED50 for angiotensin II in the subjects with 1166A/C [95% confidence interval (CI): 4.30 approximately 14.02 ng/kg/min] was significantly lower than in those with 1166A/A (95% CI: 14.23 approximately 28.77 ng/kg/min), while the E(max) for angiotensin II and EC50 for valsartan was similar in both genotype groups. CONCLUSIONS: These results suggest that exogenous human angiotensin II increases the BP more potently in subjects with 1166A/C than in those with 1166A/A. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adult | en |
dc.subject | Angiotensin II/*pharmacology | en |
dc.subject | Angiotensin II Type 1 Receptor Blockers/pharmacology | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genotype | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Receptor, Angiotensin, Type 1/agonists/*genetics | en |
dc.subject | Renin-Angiotensin System/physiology | en |
dc.subject | Tetrazoles/pharmacology | en |
dc.subject | Valine/analogs & derivatives/pharmacology | en |
dc.subject | Blood Pressure | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.title | Angiotensin II type 1 receptor 1166A/C polymorphism in association with blood pressure response to exogenous angiotensin II | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 임형석 | - |
dc.contributor.AlternativeAuthor | 조주연 | - |
dc.contributor.AlternativeAuthor | 오달석 | - |
dc.contributor.AlternativeAuthor | 정재용 | - |
dc.contributor.AlternativeAuthor | 홍경섭 | - |
dc.contributor.AlternativeAuthor | 배균섭 | - |
dc.contributor.AlternativeAuthor | 유경상 | - |
dc.contributor.AlternativeAuthor | 이경훈 | - |
dc.contributor.AlternativeAuthor | 장인진 | - |
dc.contributor.AlternativeAuthor | 신상구 | - |
dc.identifier.doi | 10.1007/s00228-006-0228-6 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.