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The anti-cancer effect of COX-2 inhibitors on gastric cancer cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho, Soo-Jeong | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.date.accessioned | 2009-12-30T02:01:02Z | - |
dc.date.available | 2009-12-30T02:01:02Z | - |
dc.date.issued | 2007-03-30 | - |
dc.identifier.citation | Dig Dis Sci. 2007 Jul;52(7):1713-21. Epub 2007 Mar 28. | en |
dc.identifier.issn | 0163-2116 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17393325 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23422 | - |
dc.description.abstract | Epidemiologic studies have shown that nonsteroidal anti-inflammatory drugs could reduce the risk of cancer development including gastric cancer. This study was performed to identify the antineoplastic mechanism in gastric cancer cells affected by celecoxib, a selective COX-2 inhibitor. MTT assay, ELISA for prostaglandin E(2) (PGE(2)), cell-cycle analyses, immunofluorescent staining, and flow cytometry were performed after treating human gastric cancer cell lines (AGS and MKN-45) with celecoxib or indomethacin. The viabilities of celecoxib-treated cells decreased in a dose- and time-dependent manner compared with indomethacin. Drop of PGE(2) levels was more prominent in the presence of indomethacin than in that of celecoxib. Celecoxib arrested the cell cycle in the G(0)-G(1) phase, which reduced cell numbers in the S phase. Moreover, celecoxib increased the apoptotic cell proportions, a 4-fold increase over control cells. The anticancer effects of celecoxib on gastric cancer cells appear to be mediated by cell-cycle arrest and apoptosis, and not by COX-2 or PGE(2) suppression alone. | en |
dc.language.iso | en | en |
dc.publisher | Springer Verlag | en |
dc.subject | Adenocarcinoma/*drug therapy/metabolism | en |
dc.subject | Apoptosis/drug effects | en |
dc.subject | Cell Cycle/drug effects | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cyclooxygenase 2 Inhibitors/pharmacology/*therapeutic use | en |
dc.subject | Dinoprostone/metabolism | en |
dc.subject | Humans | en |
dc.subject | Microscopy, Fluorescence | en |
dc.subject | Pyrazoles/pharmacology/*therapeutic use | en |
dc.subject | Stomach Neoplasms/*drug therapy/metabolism | en |
dc.subject | Sulfonamides/pharmacology/*therapeutic use | en |
dc.subject | Tetrazolium Salts/diagnostic use | en |
dc.subject | Thiazoles/diagnostic use | en |
dc.title | The anti-cancer effect of COX-2 inhibitors on gastric cancer cells | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 조수정 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.1007/s10620-007-9787-3 | - |
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