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Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia

Cited 64 time in Web of Science Cited 75 time in Scopus
Authors
Choi, Jaewon; Hwang, Yu Kyeong; Sung, Ki Woong; Lee, Soo Hyun; Yoo, Keon Hee; Jung, Hye Lim; Koo, Hong Hoe; Kim, Hee-Jin; Kang, Hyong Jin; Shin, Hee Young; Ahn, Hyo Seop
Issue Date
2007
Publisher
American Society of Hematology
Citation
Blood 2007;109:471-477
Keywords
Adaptor Proteins, Signal Transducing/biosynthesis/*geneticsAdolescentAntineoplastic Combined Chemotherapy Protocols/therapeutic useCell Proliferation/drug effectsChildChild, PreschoolFemaleFollow-Up Studies*Gene Expression ProfilingGene Expression Regulation, Leukemic/*geneticsHumansInfantInhibitor of Apoptosis Proteins/biosynthesis/*geneticsMaleMethylprednisolone/pharmacologyMolecular Sequence DataNeoplasm Proteins/biosynthesis/*geneticsPrecursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis/drugtherapy/*geneticsPredictive Value of TestsPrognosisRNA, Messenger/biosynthesis/geneticsRecurrenceReverse Transcriptase Polymerase Chain Reaction/methodsSurvival RateTreatment OutcomeTumor Markers, Biological/*genetics
Abstract
Livin, a member of the inhibitor of apoptosis proteins, has been considered to be a poor prognostic marker in malignancies. However, little is known about the clinical relevance of Livin expression in childhood acute lymphoblastic leukemia (ALL). In this study, the expression of Livin was analyzed in 222 patients with childhood ALL using quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate a possible association with the clinical features at diagnosis and treatment outcomes. Both Livin expression rates and expression levels were higher in patients with favorable prognostic factors. The expression rate was also higher in patients with a favorable day 7 bone marrow response to induction chemotherapy (P<.001). The Livin expression was related to the absence of relapse (P<.001). Similarly, the relapse-free survival rate (+/-95% CI) was higher in patients with Livin expression than in patients without Livin expression (97.9%+/-4.0% versus 64.9%+/-11.8%, P<.001). Multivariate analysis for relapse-free survival demonstrated that Livin expression was an independent favorable prognostic factor in childhood ALL (P=.049). This study suggests that Livin expression is a novel prognostic marker in childhood ALL and thus needs to be incorporated into the patient stratification and treatment protocols.
ISSN
0006-4971 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16990595

http://hdl.handle.net/10371/23431
DOI
https://doi.org/10.1182/blood-2006-07-032557
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Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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