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Transient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortex

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dc.contributor.authorKang, Ung Gu-
dc.contributor.authorJeon, Won Je-
dc.contributor.authorKim, Yeni-
dc.contributor.authorChung, Chun Kee-
dc.contributor.authorPark, Joo Bae-
dc.contributor.authorJuhnn, Yong Sung-
dc.contributor.authorKim, Yong Sik-
dc.date.accessioned2009-12-31T01:29:44Z-
dc.date.available2009-12-31T01:29:44Z-
dc.date.issued2005-09-07-
dc.identifier.citationNeurosci Lett. 2005 Dec 30;390(3):171-5. Epub 2005 Sep 6.en
dc.identifier.issn0304-3940 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16143450-
dc.identifier.urihttps://hdl.handle.net/10371/23901-
dc.description.abstractWe have attempted to determine the effects of electroconvulsive shock (ECS) on protein phosphatase 2A (PP2A) in the frontal cortices of rats. PP2A exhibited a 30% increase in activity immediately after ECS treatment. Immunoblot analysis revealed that phosphorylation signals, including protein kinase B (Akt/PKB), glycogen synthase kinase-3beta (GSK-3beta), and cyclic adenosine monophosphate response element binding protein (CREB) were reduced immediately after ECS treatment. When an additional ECS was administered after the activation of these kinases, the immediate reactivation of PP2A overrode the kinase activity. ECS induces transient PP2A activation prior to kinase activation, and this pattern of activity may induce the biphasic phosphorylation of substrate proteins.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAnalysis of Varianceen
dc.subjectAnimalsen
dc.subjectBlotting, Western/methodsen
dc.subjectDose-Response Relationship, Radiationen
dc.subjectElectroshock/*methodsen
dc.subjectEnzyme Activation/radiation effectsen
dc.subjectFrontal Lobe/metabolism/*radiation effectsen
dc.subjectGene Expression Regulation/*radiation effectsen
dc.subjectMaleen
dc.subjectPhosphoprotein Phosphatases/*metabolismen
dc.subjectPhosphorylation/radiation effectsen
dc.subjectProtein Kinases/metabolismen
dc.subjectProtein Phosphatase 2en
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectSerine/metabolismen
dc.subjectThreonine/metabolismen
dc.subjectTime Factorsen
dc.titleTransient activation of protein phosphatase 2A induced by electroconvulsive shock in the rat frontal cortexen
dc.typeArticleen
dc.contributor.AlternativeAuthor강웅구-
dc.contributor.AlternativeAuthor전원제-
dc.contributor.AlternativeAuthor김예니-
dc.contributor.AlternativeAuthor정천기-
dc.contributor.AlternativeAuthor박주배-
dc.contributor.AlternativeAuthor전용성-
dc.contributor.AlternativeAuthor김용식-
dc.identifier.doi10.1016/j.neulet.2005.08.020-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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