S-Space College of Medicine/School of Medicine (의과대학/대학원) Anatomy (해부학전공) Journal Papers (저널논문_해부학전공)
Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus
- Jeon, Gye Sun; Byun, Hee Jine; Park, Sung Kyung; Park, Sang Wook; Kim, Dong Woon; Seo, Je Hoon; Cha, Chong Ik; Cho, San Sun
- Issue Date
- Springer Verlag
- Neurochem Res. 2006 Nov;31(11):1371-4. Epub 2006 Oct 20.
- Animals; Astrocytes/drug effects/*metabolism; Blotting, Western; Densitometry; Excitatory Amino Acid Agonists/administration & dosage/*toxicity; Fluorescent Antibody Technique; Hippocampus/*pathology; Immunohistochemistry; Injections, Intraventricular; Kainic Acid/administration & dosage/*toxicity; Male; Mice; Mice, Inbred ICR; Proto-Oncogene Proteins/*biosynthesis; Signal Transduction/drug effects; Trans-Activators/*biosynthesis
- In the present study, we examined patterns of A-myb expression in the kainic acid (KA)-treated mouse hippocampus. Western blot analysis revealed that A-myb expression was dramatically increased in brain 3 days after KA treatment, and was sustained for more than 7 days. A-myb immunoreactivity was restricted to hippocampal neurons in control mice. Three days after KA treatment, strong A-myb immunoreactivity was observed in reactive astrocytes throughout the CA3 region. Thereafter, A-myb immunoreactive astrocytes gradually concentrated around the CA3 region in parallel with selective neuronal loss, and only a few A-myb immunoreactive astrocytes persisted in the CA3 region 14 days after KA treatment. These findings suggest that the A-myb plays a role in the reactive gliosis signaling pathway in KA-induced excitotoxic lesions.
- 0364-3190 (Print)
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