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Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus
Cited 2 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2006-10-21
- Publisher
- Springer Verlag
- Citation
- Neurochem Res. 2006 Nov;31(11):1371-4. Epub 2006 Oct 20.
- Keywords
- Animals ; Astrocytes/drug effects/*metabolism ; Blotting, Western ; Densitometry ; Excitatory Amino Acid Agonists/administration & dosage/*toxicity ; Fluorescent Antibody Technique ; Hippocampus/*pathology ; Immunohistochemistry ; Injections, Intraventricular ; Kainic Acid/administration & dosage/*toxicity ; Male ; Mice ; Mice, Inbred ICR ; Proto-Oncogene Proteins/*biosynthesis ; Signal Transduction/drug effects ; Trans-Activators/*biosynthesis
- Abstract
- In the present study, we examined patterns of A-myb expression in the kainic acid (KA)-treated mouse hippocampus. Western blot analysis revealed that A-myb expression was dramatically increased in brain 3 days after KA treatment, and was sustained for more than 7 days. A-myb immunoreactivity was restricted to hippocampal neurons in control mice. Three days after KA treatment, strong A-myb immunoreactivity was observed in reactive astrocytes throughout the CA3 region. Thereafter, A-myb immunoreactive astrocytes gradually concentrated around the CA3 region in parallel with selective neuronal loss, and only a few A-myb immunoreactive astrocytes persisted in the CA3 region 14 days after KA treatment. These findings suggest that the A-myb plays a role in the reactive gliosis signaling pathway in KA-induced excitotoxic lesions.
- ISSN
- 0364-3190 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17053967
https://hdl.handle.net/10371/23911
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