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Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Gye Sun | - |
dc.contributor.author | Byun, Hee Jine | - |
dc.contributor.author | Park, Sung Kyung | - |
dc.contributor.author | Park, Sang Wook | - |
dc.contributor.author | Kim, Dong Woon | - |
dc.contributor.author | Seo, Je Hoon | - |
dc.contributor.author | Cha, Chong Ik | - |
dc.contributor.author | Cho, San Sun | - |
dc.date.accessioned | 2009-12-31T01:35:55Z | - |
dc.date.available | 2009-12-31T01:35:55Z | - |
dc.date.issued | 2006-10-21 | - |
dc.identifier.citation | Neurochem Res. 2006 Nov;31(11):1371-4. Epub 2006 Oct 20. | en |
dc.identifier.issn | 0364-3190 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17053967 | - |
dc.identifier.uri | https://hdl.handle.net/10371/23911 | - |
dc.description.abstract | In the present study, we examined patterns of A-myb expression in the kainic acid (KA)-treated mouse hippocampus. Western blot analysis revealed that A-myb expression was dramatically increased in brain 3 days after KA treatment, and was sustained for more than 7 days. A-myb immunoreactivity was restricted to hippocampal neurons in control mice. Three days after KA treatment, strong A-myb immunoreactivity was observed in reactive astrocytes throughout the CA3 region. Thereafter, A-myb immunoreactive astrocytes gradually concentrated around the CA3 region in parallel with selective neuronal loss, and only a few A-myb immunoreactive astrocytes persisted in the CA3 region 14 days after KA treatment. These findings suggest that the A-myb plays a role in the reactive gliosis signaling pathway in KA-induced excitotoxic lesions. | en |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | en |
dc.subject | Animals | en |
dc.subject | Astrocytes/drug effects/*metabolism | en |
dc.subject | Blotting, Western | en |
dc.subject | Densitometry | en |
dc.subject | Excitatory Amino Acid Agonists/administration & dosage/*toxicity | en |
dc.subject | Fluorescent Antibody Technique | en |
dc.subject | Hippocampus/*pathology | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Injections, Intraventricular | en |
dc.subject | Kainic Acid/administration & dosage/*toxicity | en |
dc.subject | Male | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred ICR | en |
dc.subject | Proto-Oncogene Proteins/*biosynthesis | en |
dc.subject | Signal Transduction/drug effects | en |
dc.subject | Trans-Activators/*biosynthesis | en |
dc.title | Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 전계선 | - |
dc.contributor.AlternativeAuthor | 변희진 | - |
dc.contributor.AlternativeAuthor | 박성경 | - |
dc.contributor.AlternativeAuthor | 박상욱 | - |
dc.contributor.AlternativeAuthor | 김동운 | - |
dc.contributor.AlternativeAuthor | 서제훈 | - |
dc.contributor.AlternativeAuthor | 차충익 | - |
dc.contributor.AlternativeAuthor | 조사선 | - |
dc.identifier.doi | 10.1007/s11064-006-9184-x | - |
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