Publications
Detailed Information
Association between the MLH1 gene and longevity
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kim, Dong Jo | - |
| dc.contributor.author | Yi, Sang Mi | - |
| dc.contributor.author | Lee, Seung Yeon | - |
| dc.contributor.author | Kang, Heun Soo | - |
| dc.contributor.author | Choi, Yoon-Ho | - |
| dc.contributor.author | Song, Yeong Wook | - |
| dc.contributor.author | Park, Sang Chul | - |
| dc.date.accessioned | 2009-12-31T04:43:41Z | - |
| dc.date.available | 2009-12-31T04:43:41Z | - |
| dc.date.issued | 2006-02-14 | - |
| dc.identifier.citation | Hum Genet. 2006 Apr;119(3):353-4. Epub 2006 Feb 11. | en |
| dc.identifier.issn | 0340-6717 (Print) | - |
| dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16474933 | - |
| dc.identifier.uri | https://hdl.handle.net/10371/24325 | - |
| dc.description.abstract | Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity. | en |
| dc.language.iso | en | en |
| dc.publisher | Springer Verlag | en |
| dc.subject | Adaptor Proteins, Signal Transducing | en |
| dc.subject | Aged | en |
| dc.subject | Aged, 80 and over | en |
| dc.subject | Carrier Proteins/*genetics | en |
| dc.subject | Female | en |
| dc.subject | Gene Frequency | en |
| dc.subject | Genetic Screening/methods | en |
| dc.subject | Haplotypes | en |
| dc.subject | Humans | en |
| dc.subject | Longevity/*genetics | en |
| dc.subject | Male | en |
| dc.subject | Middle Aged | en |
| dc.subject | Nuclear Proteins/*genetics | en |
| dc.subject | Polymorphism, Single Nucleotide | en |
| dc.title | Association between the MLH1 gene and longevity | en |
| dc.type | Article | en |
| dc.contributor.AlternativeAuthor | 김동조 | - |
| dc.contributor.AlternativeAuthor | 이상미 | - |
| dc.contributor.AlternativeAuthor | 이승연 | - |
| dc.contributor.AlternativeAuthor | 강현수 | - |
| dc.contributor.AlternativeAuthor | 최윤호 | - |
| dc.contributor.AlternativeAuthor | 송영욱 | - |
| dc.contributor.AlternativeAuthor | 박상철 | - |
| dc.identifier.doi | 10.1007/s00439-006-0148-7 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.