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Association between the MLH1 gene and longevity

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dc.contributor.authorKim, Dong Jo-
dc.contributor.authorYi, Sang Mi-
dc.contributor.authorLee, Seung Yeon-
dc.contributor.authorKang, Heun Soo-
dc.contributor.authorChoi, Yoon-Ho-
dc.contributor.authorSong, Yeong Wook-
dc.contributor.authorPark, Sang Chul-
dc.date.accessioned2009-12-31T04:43:41Z-
dc.date.available2009-12-31T04:43:41Z-
dc.date.issued2006-02-14-
dc.identifier.citationHum Genet. 2006 Apr;119(3):353-4. Epub 2006 Feb 11.en
dc.identifier.issn0340-6717 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16474933-
dc.identifier.urihttps://hdl.handle.net/10371/24325-
dc.description.abstractPerturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectAdaptor Proteins, Signal Transducingen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectCarrier Proteins/*geneticsen
dc.subjectFemaleen
dc.subjectGene Frequencyen
dc.subjectGenetic Screening/methodsen
dc.subjectHaplotypesen
dc.subjectHumansen
dc.subjectLongevity/*geneticsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNuclear Proteins/*geneticsen
dc.subjectPolymorphism, Single Nucleotideen
dc.titleAssociation between the MLH1 gene and longevityen
dc.typeArticleen
dc.contributor.AlternativeAuthor김동조-
dc.contributor.AlternativeAuthor이상미-
dc.contributor.AlternativeAuthor이승연-
dc.contributor.AlternativeAuthor강현수-
dc.contributor.AlternativeAuthor최윤호-
dc.contributor.AlternativeAuthor송영욱-
dc.contributor.AlternativeAuthor박상철-
dc.identifier.doi10.1007/s00439-006-0148-7-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biochemistry & Molecular Biology (생화학교실)Journal Papers (저널논문_생화학교실)
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