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Association between the MLH1 gene and longevity
Cited 12 time in
Web of Science
Cited 14 time in Scopus
- Authors
- Issue Date
- 2006-02-14
- Publisher
- Springer Verlag
- Citation
- Hum Genet. 2006 Apr;119(3):353-4. Epub 2006 Feb 11.
- Keywords
- Adaptor Proteins, Signal Transducing ; Aged ; Aged, 80 and over ; Carrier Proteins/*genetics ; Female ; Gene Frequency ; Genetic Screening/methods ; Haplotypes ; Humans ; Longevity/*genetics ; Male ; Middle Aged ; Nuclear Proteins/*genetics ; Polymorphism, Single Nucleotide
- Abstract
- Perturbations in genomic stability result in cancer, a reduced life span, and premature aging. MLH1 is a mismatch repair enzyme that acts to maintain genomic stability, and a loss of MLH1 increases cancer incidence and apoptosis resistance, which suggests a link between MLH1 and longevity. We found here that MLH1 is associated with longevity by comparing a centenarian group with a control group. Our data indicate a critical role for MLH1 in longevity.
- ISSN
- 0340-6717 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16474933
https://hdl.handle.net/10371/24325
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