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A new calcineurin inhibition domain in Cabin1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Hyonchol | - |
dc.contributor.author | Cho, Eun-Jung | - |
dc.contributor.author | Youn, Hong-Duk | - |
dc.date.accessioned | 2009-12-31T04:56:51Z | - |
dc.date.available | 2009-12-31T04:56:51Z | - |
dc.date.issued | 2007-05-29 | - |
dc.identifier.citation | Biochem Biophys Res Commun. 2007 Jul 20;359(1):129-35. Epub 2007 May 21. | en |
dc.identifier.issn | 0006-291X (Print) | - |
dc.identifier.uri | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4NSR1JX-K&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6042cd12b6085c7ae0a786fc6913f9e0 | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17531200 | - |
dc.identifier.uri | https://hdl.handle.net/10371/24357 | - |
dc.description.abstract | Calcineurin (CN), a calcium-activated phosphatase, plays a critical role in various biological processes including T cell activation. Cabin1, a calcineurin binding protein 1, has been shown to bind directly to CN using its C-terminal region and inhibit CN activity. However, no increase in CN activity has been found in Cabin1DeltaC T cells, which produce a truncated Cabin1 lacking the C-terminal CN binding region. Here, we report that Cabin1 has additional CN binding domain in its 701-900 amino acid residues. Cabin1 (701-900) blocked both CN-mediated dephosphorylation and nuclear import of NFAT and thus inhibited IL-2 production in response to PMA/ionomycin stimulation. This fact may explain why Cabin1DeltaC mice previously showed no significant defect in CN-mediated signaling pathway. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Calcineurin/*chemistry/*metabolism | en |
dc.subject | Enzyme Activation | en |
dc.subject | Enzyme Inhibitors/chemistry/metabolism | en |
dc.subject | Humans | en |
dc.subject | Jurkat Cells | en |
dc.subject | Protein Binding | en |
dc.title | A new calcineurin inhibition domain in Cabin1 | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 장현철 | - |
dc.contributor.AlternativeAuthor | 조은정 | - |
dc.contributor.AlternativeAuthor | 윤홍덕 | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.05.066 | - |
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