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A new calcineurin inhibition domain in Cabin1

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dc.contributor.authorJang, Hyonchol-
dc.contributor.authorCho, Eun-Jung-
dc.contributor.authorYoun, Hong-Duk-
dc.date.accessioned2009-12-31T04:56:51Z-
dc.date.available2009-12-31T04:56:51Z-
dc.date.issued2007-05-29-
dc.identifier.citationBiochem Biophys Res Commun. 2007 Jul 20;359(1):129-35. Epub 2007 May 21.en
dc.identifier.issn0006-291X (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4NSR1JX-K&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=6042cd12b6085c7ae0a786fc6913f9e0-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17531200-
dc.identifier.urihttps://hdl.handle.net/10371/24357-
dc.description.abstractCalcineurin (CN), a calcium-activated phosphatase, plays a critical role in various biological processes including T cell activation. Cabin1, a calcineurin binding protein 1, has been shown to bind directly to CN using its C-terminal region and inhibit CN activity. However, no increase in CN activity has been found in Cabin1DeltaC T cells, which produce a truncated Cabin1 lacking the C-terminal CN binding region. Here, we report that Cabin1 has additional CN binding domain in its 701-900 amino acid residues. Cabin1 (701-900) blocked both CN-mediated dephosphorylation and nuclear import of NFAT and thus inhibited IL-2 production in response to PMA/ionomycin stimulation. This fact may explain why Cabin1DeltaC mice previously showed no significant defect in CN-mediated signaling pathway.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectCalcineurin/*chemistry/*metabolismen
dc.subjectEnzyme Activationen
dc.subjectEnzyme Inhibitors/chemistry/metabolismen
dc.subjectHumansen
dc.subjectJurkat Cellsen
dc.subjectProtein Bindingen
dc.titleA new calcineurin inhibition domain in Cabin1en
dc.typeArticleen
dc.contributor.AlternativeAuthor장현철-
dc.contributor.AlternativeAuthor조은정-
dc.contributor.AlternativeAuthor윤홍덕-
dc.identifier.doi10.1016/j.bbrc.2007.05.066-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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