S-Space College of Medicine/School of Medicine (의과대학/대학원) Program in Clinical Pharmacology (협동과정-임상약리학전공) Journal Papers (저널논문_협동과정-임상약리학전공)
White matter abnormalities in drug-naive patients with obsessive-compulsive disorder: a diffusion tensor study before and after citalopram treatment
- Yoo, S Y; Jang, J H; Shin, Y-W; Kim, D J; Park, H-J; Moon, W-J; Chung, E C; Lee, J-M; Kim, I Y; Kim, S I; Kwon, J S
- Issue Date
- Acta Psychiatr Scand. 2007 Sep;116(3):211-9.
- Adult; Anisotropy; Antidepressive Agents, Second-Generation/adverse effects/*therapeutic use; Brain/*drug effects; Caudate Nucleus/drug effects/pathology; Cerebral Cortex/drug effects/pathology; Citalopram/adverse effects/*therapeutic use; Corpus Callosum/drug effects/pathology; *Diffusion Magnetic Resonance Imaging; Dominance, Cerebral/physiology; Female; Fourier Analysis; Humans; *Image Processing, Computer-Assisted; Internal Capsule/drug effects/pathology; *Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated/*drug effects/pathology; Obsessive-Compulsive Disorder/diagnosis/*drug therapy; Thalamus/drug effects/pathology
- OBJECTIVE: The aim was to investigate the white matter abnormalities of drug-naive patients with obsessive-compulsive disorder (OCD) using diffusion tensor-imaging and the white matter changes in the patients after pharmacotherapy. METHOD: Thirteen drug-naive OCD patients and 13 age- and sex-matched healthy comparison subjects were examined using diffusion tensor-imaging and structural magnetic resonance imaging. Measurements were made in OCD patients before and after 12 weeks of citalopram treatment. RESULTS: Compared with controls, the drug-naive OCD patients showed significant increases in fractional anisotropy (FA) in the corpus callosum, the internal capsule and white matter in the area superolateral to the right caudate. The increases in FA were mostly no longer observed in patients after 12 weeks of treatment compared with controls. CONCLUSION: Our findings suggest that white matter alterations are associated with the pathophysiology of OCD, and the abnormalities may be partly reversible with pharmacotherapy.
- 0001-690X (Print)
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