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Worldwide variation of dialysis-associated peritonitis in children

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dc.contributor.authorSchaefer, F-
dc.contributor.authorFeneberg, R-
dc.contributor.authorAksu, N-
dc.contributor.authorDonmez, O-
dc.contributor.authorSadikoglu, B-
dc.contributor.authorAlexander, S R-
dc.contributor.authorMir, S-
dc.contributor.authorHa, I S-
dc.contributor.authorFischbach, M-
dc.contributor.authorSimkova, E-
dc.contributor.authorWatson, A R-
dc.contributor.authorMoller, K-
dc.contributor.authorvon Baum, H-
dc.contributor.authorWarady, B A-
dc.date.accessioned2010-01-04-
dc.date.available2010-01-04-
dc.date.issued2007-
dc.identifier.citationKidney Int 2007; 72: 1374-1379en
dc.identifier.issn0085-2538 (Print)-
dc.identifier.urihttp://www.nature.com/ki/journal/v72/n11/abs/5002523a.html-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17882152-
dc.identifier.urihttps://hdl.handle.net/10371/24802-
dc.description.abstractPeritonitis is the most common cause of dialysis failure in children on chronic peritoneal dialysis. We performed a prospective study of 501 peritonitis episodes in 44 pediatric dialysis centers located in 14 countries that examined peritonitis etiology, efficiency of opinion-based management guidelines, and final outcomes. Culture-negative incidence varied significantly from 11% in North America to 67% in Mexico. Argentina and North America had the highest rate of Gram-negative episodes. Pseudomonas-based peritonitis was eightfold more common in the United States than in Europe, and correlated with the frequency of exit site cleansing and topical mupirocin administration. Significant regional variation in antibiotic susceptibility was noted for the first generation cephalosporins and aminoglycosides. Initial response rates to standardized empiric antibiotic treatment did not differ between regions; however, final outcomes were significantly less favorable in Eastern Europe. The wide regional variation in culture-negative peritonitis, and the distribution and antibiotic susceptibilities of causative bacteria needs to be taken into consideration when the guidelines for empiric therapy of pediatric dialysis-associated peritonitis are revised.en
dc.description.sponsorshipThe IPPR was kindly supported by Baxter Healthcare and the
International Society for Peritoneal Dialysis.
en
dc.language.isoen-
dc.publisherNature Publishing Groupen
dc.subjectAdolescenten
dc.subjectAnti-Bacterial Agents/*therapeutic useen
dc.subjectArgentinaen
dc.subjectAsiaen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDrug Resistance, Bacterialen
dc.subjectEuropeen
dc.subjectGram-Negative Bacterial Infections/drug therapy/etiologyen
dc.subjectGram-Positive Bacterial Infections/drug therapy/etiologyen
dc.subjectHumansen
dc.subjectIncidenceen
dc.subjectInfanten
dc.subjectInfant, Newbornen
dc.subjectInternational Cooperationen
dc.subjectMexicoen
dc.subjectPeritoneal Dialysis/*adverse effectsen
dc.subjectPeritonitis/*drug therapy/*etiology/microbiologyen
dc.subjectProspective Studiesen
dc.subjectRegistries/*statistics & numerical dataen
dc.subjectTreatment Outcomeen
dc.subjectTurkeyen
dc.subjectUnited Statesen
dc.subjectPractice Guidelines as Topic-
dc.titleWorldwide variation of dialysis-associated peritonitis in childrenen
dc.typeArticleen
dc.identifier.doi10.1038/sj.ki.5002523-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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