Publications

Detailed Information

Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy

DC Field Value Language
dc.contributor.authorKim, Seog Ju-
dc.contributor.authorLyoo, In Kyoon-
dc.contributor.authorLee, Yujin S-
dc.contributor.authorSung, Young Hoon-
dc.contributor.authorKim, Hengjun J-
dc.contributor.authorKim, Jihyun H-
dc.contributor.authorKim, Kye Hyun-
dc.contributor.authorJeong, Do-Un-
dc.date.accessioned2010-01-04T07:19:24Z-
dc.date.available2010-01-04T07:19:24Z-
dc.date.issued2008-
dc.identifier.citationSleep 2008;31:342-7en
dc.identifier.issn0161-8105 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18363310-
dc.identifier.urihttps://hdl.handle.net/10371/24906-
dc.description.abstractSTUDY OBJECTIVES: To explore absolute concentrations of brain metabolites including gamma amino-butyric acid (GABA) in the medial prefrontal cortex and basal ganglia of young adults with narcolepsy. DESIGN: Proton magnetic resonance (MR) spectroscopy centered on the medial prefrontal cortex and the basal ganglia was acquired. The absolute concentrations of brain metabolites including GABA and glutamate were assessed and compared between narcoleptic patients and healthy comparison subjects. SETTING: Sleep and Chronobiology Center at Seoul National University Hospital; A high strength 3.0 Tesla MR scanner in the Department of Radiology at Seoul National University Hospital. PATIENTS OR PARTICIPANTS: Seventeen young adults with a sole diagnosis of HLA DQB1 0602 positive narcolepsy with cataplexy (25.1 +/- 4.6 years old) and 17 healthy comparison subjects (26.8 +/- 4.8 years old). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: Relative to comparison subjects, narcoleptic patients had higher GABA concentration in the medial prefrontal cortex (t = 4.10, P <0.001). Narcoleptic patients with nocturnal sleep disturbance had higher GABA concentration in the medial prefrontal cortex than those without nocturnal sleep disturbance (t = 2.45, P = 0.03), but had lower GABA concentration than comparison subjects (t = 2.30, P = 0.03). CONCLUSIONS: The current study reports that young adults with narcolepsy had a higher GABA concentration in the medial prefrontal cortex, which was more prominent in patients without nocturnal sleep disturbance. Our findings suggest that the medial prefrontal GABA level may be increased in narcolepsy, and the increased medial prefrontal GABA might be a compensatory mechanism to reduce nocturnal sleep disturbances in narcolepsy.en
dc.language.isoen-
dc.publisherAmerican Academy of Sleep Medicineen
dc.subjectAdulten
dc.subjectBasal Ganglia/physiopathologyen
dc.subjectCataplexy/diagnosis/genetics/physiopathologyen
dc.subjectFemaleen
dc.subjectGenotypeen
dc.subjectGlutamic Acid/metabolismen
dc.subjectHLA-DQ Antigens/geneticsen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMembrane Glycoproteins/geneticsen
dc.subjectNarcolepsy/diagnosis/genetics/*physiopathologyen
dc.subjectPrefrontal Cortex/*physiopathologyen
dc.subjectReference Valuesen
dc.subjectSleep Disorders, Circadian Rhythm/diagnosis/genetics/physiopathologyen
dc.subjectgamma-Aminobutyric Acid/*metabolismen
dc.subjectMagnetic Resonance Imaging-
dc.subjectMagnetic Resonance Spectroscopy-
dc.titleIncreased GABA levels in medial prefrontal cortex of young adults with narcolepsyen
dc.typeArticleen
dc.contributor.AlternativeAuthor김석주-
dc.contributor.AlternativeAuthor류인균-
dc.contributor.AlternativeAuthor이유진-
dc.contributor.AlternativeAuthor성영훈-
dc.contributor.AlternativeAuthor김행준-
dc.contributor.AlternativeAuthor김지현-
dc.contributor.AlternativeAuthor김계현-
dc.contributor.AlternativeAuthor정도언-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share