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GSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational population

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dc.contributor.authorKim, J. H.-
dc.contributor.authorLee, K. H.-
dc.contributor.authorYoo, D. H.-
dc.contributor.authorKang, D.-
dc.contributor.authorCho, S. H.-
dc.contributor.authorHong, Y. C.-
dc.date.accessioned2010-01-06T02:13:57Z-
dc.date.available2010-01-06T02:13:57Z-
dc.date.issued2007-02-15-
dc.identifier.citationMutat Res. 2007 Apr 20;629(1):32-9. Epub 2007 Jan 13.en
dc.identifier.issn0027-5107 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17298885-
dc.identifier.urihttps://hdl.handle.net/10371/25952-
dc.description.abstractInflammation is known to be an important underlying condition in the development of a variety of diseases. To investigate whether blood lead induces inflammatory reactions in non-occupationally exposed adults and the effects of genetic susceptibility associated with GSTM1 and TNF-alpha gene polymorphisms on this inflammatory response, we measured blood lead levels in 300 healthy university students. Total serum TNF-alpha and IL-6 levels and WBC counts were determined to evaluate the inflammatory response. Allelic loss of GSTM1 and the TNF-alpha-308 G>A polymorphism were determined by PCR and RFLP. Positive relations between blood lead and three inflammation biomarkers were shown in male subjects with blood lead > or =2.51microg/dl (median value) (TNF-alpha, p=0.015; IL-6, p=0.082; and WBC, p=0.044). However, subgroup analysis by genotype showed an effect of blood lead on the three biomarkers only in individuals with the GSTM1 null (TNF-alpha, p=0.020; IL-6, p=0.096; and WBC, p=0.017) or TNF-alpha GG (TNF-alpha, p=0.017; IL-6, p=0.088; and WBC, p=0.095) genotype, and not in individuals with GSTM1 present (all three inflammatory biomarkers, p>0.1) or the TNF-alpha GA or AA (all three biomarkers, p>0.1) genotype. These results suggest that blood lead affects the inflammatory response and that GSTM1 and TNF-alpha gene polymorphisms are genetic factors associated with lead-induced inflammatory response.en
dc.language.isoen-
dc.subjectAdulten
dc.subjectAllelesen
dc.subjectBiological Markers/blooden
dc.subjectEnzyme-Linked Immunosorbent Assayen
dc.subjectFemaleen
dc.subjectGlutathione Transferase/*geneticsen
dc.subjectHumansen
dc.subjectInflammation/*blooden
dc.subjectInterleukin-6/blooden
dc.subjectLead/*blooden
dc.subjectLeukocyte Counten
dc.subjectMaleen
dc.subjectPolymerase Chain Reactionen
dc.subjectPolymorphism, Restriction Fragment Lengthen
dc.subjectStudentsen
dc.subjectTumor Necrosis Factor-alpha/blood/*geneticsen
dc.subjectPolymorphism, Genetic-
dc.titleGSTM1 and TNF-alpha gene polymorphisms and relations between blood lead and inflammatory markers in a non-occupational populationen
dc.typeArticleen
dc.contributor.AlternativeAuthor김진희-
dc.contributor.AlternativeAuthor이관희-
dc.contributor.AlternativeAuthor유동호-
dc.contributor.AlternativeAuthor강대희-
dc.contributor.AlternativeAuthor조수헌-
dc.contributor.AlternativeAuthor홍윤철-
dc.identifier.doi10.1016/j.mrgentox.2007.01.004-
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