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Development of acetylated HDD kit for preparation of 188Re-HDD/lipiodol

DC Field Value Language
dc.contributor.authorLee, Yun-Sang-
dc.contributor.authorJeong, Jae Min-
dc.contributor.authorKim, Young Joo-
dc.contributor.authorChang, Young Soo-
dc.contributor.authorLee, Hak Jeong-
dc.contributor.authorSon, Miwon-
dc.contributor.authorLee, Jung Woo-
dc.contributor.authorYoon, Heung Sik-
dc.contributor.authorKang, Won Jun-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorChung, June-Key-
dc.contributor.authorLee, Myung Chul-
dc.contributor.authorSuh, Young-Ger-
dc.date.accessioned2010-01-06T04:07:12Z-
dc.date.available2010-01-06T04:07:12Z-
dc.date.issued2006-10-03-
dc.identifier.citationAppl Radiat Isot. 2007 Jan;65(1):64-9. Epub 2006 Sep 28.en
dc.identifier.issn0969-8043 (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TJ0-4M0J4DP-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=3e41c04004cc24a1ba9bbd5044745eaf-
dc.identifier.urihttps://hdl.handle.net/10371/26061-
dc.description.abstractA lipiodol solution of (188)Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol ((188)Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectAcetylationen
dc.subjectAnimalsen
dc.subjectEquipment Designen
dc.subjectEquipment Failure Analysisen
dc.subjectIodized Oil/*chemical synthesis/diagnosticen
dc.subjectuse/*pharmacokinetics/therapeutic useen
dc.subjectIsotope Labeling/*instrumentation/methodsen
dc.subjectMetabolic Clearance Rateen
dc.subjectMiceen
dc.subjectOrgan Specificityen
dc.subjectOrganometallic Compounds/*chemical synthesis/diagnosticen
dc.subjectuse/*pharmacokinetics/therapeutic useen
dc.subjectRadiopharmaceuticals/chemical synthesis/diagnosticen
dc.subjectuse/pharmacokinetics/therapeutic useen
dc.subjectTissue Distributionen
dc.subjectReagent Kits, Diagnostic-
dc.titleDevelopment of acetylated HDD kit for preparation of 188Re-HDD/lipiodolen
dc.typeArticleen
dc.contributor.AlternativeAuthor이윤상-
dc.contributor.AlternativeAuthor정재민-
dc.contributor.AlternativeAuthor김영주-
dc.contributor.AlternativeAuthor장영수-
dc.contributor.AlternativeAuthor이학정-
dc.contributor.AlternativeAuthor손미원-
dc.contributor.AlternativeAuthor이정우-
dc.contributor.AlternativeAuthor윤흥식-
dc.contributor.AlternativeAuthor강원준-
dc.contributor.AlternativeAuthor이동수-
dc.contributor.AlternativeAuthor정준기-
dc.contributor.AlternativeAuthor이명철-
dc.contributor.AlternativeAuthor서영거-
dc.identifier.doi10.1016/j.apradiso.2006.07.008-
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