Browse

Meta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC review

DC Field Value Language
dc.contributor.authorRaimondi, S.-
dc.contributor.authorParacchini, V.-
dc.contributor.authorAutrup, H.-
dc.contributor.authorBarros-Dios, J. M.-
dc.contributor.authorBenhamou, S.-
dc.contributor.authorBoffetta, P.-
dc.contributor.authorCote, M. L.-
dc.contributor.authorDialyna, I. A.-
dc.contributor.authorDolzan, V.-
dc.contributor.authorFiliberti, R.-
dc.contributor.authorGarte, S.-
dc.contributor.authorHirvonen, A.-
dc.contributor.authorHusgafvel-Pursiainen, K.-
dc.contributor.authorImyanitov, E. N.-
dc.contributor.authorKalina, I.-
dc.contributor.authorKang, D.-
dc.contributor.authorKiyohara, C.-
dc.contributor.authorKohno, T.-
dc.contributor.authorKremers, P.-
dc.contributor.authorLan, Q.-
dc.contributor.authorLondon, S.-
dc.contributor.authorPovey, A. C.-
dc.contributor.authorRannug, A.-
dc.contributor.authorReszka, E.-
dc.contributor.authorRisch, A.-
dc.contributor.authorRomkes, M.-
dc.contributor.authorSchneider, J.-
dc.contributor.authorSeow, A.-
dc.contributor.authorShields, P. G.-
dc.contributor.authorSobti, R. C.-
dc.contributor.authorSorensen, M.-
dc.contributor.authorSpinola, M.-
dc.contributor.authorSpitz, M. R.-
dc.contributor.authorStrange, R. C.-
dc.contributor.authorStucker, I.-
dc.contributor.authorSugimura, H.-
dc.contributor.authorTo-Figueras, J.-
dc.contributor.authorTokudome, S.-
dc.contributor.authorYang, P.-
dc.contributor.authorYuan, J. M.-
dc.contributor.authorWarholm, M.-
dc.contributor.authorTaioli, E.-
dc.date.accessioned2010-01-06T06:51:26Z-
dc.date.available2010-01-06T06:51:26Z-
dc.date.issued2006-09-27-
dc.identifier.citationAm J Epidemiol. 2006 Dec 1;164(11):1027-42. Epub 2006 Sep 25.en
dc.identifier.govdochttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17000715-
dc.identifier.issn0002-9262 (Print)-
dc.identifier.urihttps://hdl.handle.net/10371/26627-
dc.description.abstractLung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.en
dc.language.isoen-
dc.publisherOxford University Pressen
dc.subjectAsian Continental Ancestry Group/statistics & numerical dataen
dc.subjectCase-Control Studiesen
dc.subjectData Interpretation, Statisticalen
dc.subjectEuropean Continental Ancestry Group/statistics & numerical dataen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenetic Variationen
dc.subjectGenotypeen
dc.subjectGlutathione Transferase/*genetics/physiologyen
dc.subjectHumansen
dc.subjectLung Neoplasms/*enzymology/ethnology/*geneticsen
dc.subjectPolymorphism, Geneticen
dc.subjectRisk Factorsen
dc.subjectSmoking/adverse effectsen
dc.titleMeta- and pooled analysis of GSTT1 and lung cancer: a HuGE-GSEC reviewen
dc.typeArticleen
dc.identifier.doi10.1093/aje/kwj321-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse