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Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population

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dc.contributor.authorLee, Y Y-
dc.contributor.authorLee, N S-
dc.contributor.authorCho, Y M-
dc.contributor.authorMoon, M K-
dc.contributor.authorJung, H S-
dc.contributor.authorPark, Y J-
dc.contributor.authorPark, H J-
dc.contributor.authorYoun, B S-
dc.contributor.authorLee, H K-
dc.contributor.authorPark, K S-
dc.contributor.authorShin, H D-
dc.date.accessioned2010-01-06T08:14:34Z-
dc.date.available2010-01-06T08:14:34Z-
dc.date.issued2005-04-22-
dc.identifier.citationDiabet Med. 2005 May;22(5):569-75.en
dc.identifier.issn0742-3071 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15842511-
dc.identifier.urihttp://hdl.handle.net/10371/26996-
dc.description.abstractAIMS: To investigate any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population. METHODS: We genotyped 427 non-diabetic controls and 493 Type 2 diabetic patients for SNPs T45G and G276T of adiponectin gene, measured plasma adiponectin concentrations, and examined clinical parameters in Koreans. RESULTS: There were no statistically significant differences in allele frequencies of SNPs 45 and 276 comparing control with Type 2 diabetic subjects (T frequency 68.3% vs. 71.6%, P=0.13 for SNP45, G frequency 72.2% vs. 68.9%, P=0.12 for SNP276). The genotype distributions of these SNPs had no association with the risk of Type 2 diabetes and metabolic parameters of insulin resistance. Plasma levels of adiponectin were not statistically different according to T45G and G276T either, in both control and Type 2 diabetic subjects. CONCLUSION: The T45G and G276T of the adiponectin gene may not be an important determinant of Type 2 diabetes or insulin resistance in Korean subjects.en
dc.language.isoen-
dc.publisherWiley-Blackwellen
dc.subjectAdiponectinen
dc.subjectAgeden
dc.subjectDiabetes Mellitus, Type 2/ethnology/*geneticsen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Disease/*geneticsen
dc.subjectHumansen
dc.subjectInsulin Resistance/ethnology/geneticsen
dc.subject*Intercellular Signaling Peptides and Proteins/geneticsen
dc.subjectKorea/ethnologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPolymorphism, Single Nucleotide/*geneticsen
dc.titleGenetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean populationen
dc.typeArticleen
dc.identifier.doi10.1111/j.1464-5491.2005.01460.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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