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Phase II trial of low-dose paclitaxel and cisplatin in patients with advanced gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Lee, Keun-Wook | - |
dc.contributor.author | Im, Seock Ah | - |
dc.contributor.author | Yun, Tak | - |
dc.contributor.author | Song, Eun Kee | - |
dc.contributor.author | Na, Im Il | - |
dc.contributor.author | Shin, Hyunchoon | - |
dc.contributor.author | Choi, In Sil | - |
dc.contributor.author | Oh, Do Youn | - |
dc.contributor.author | Kim, Jee Hyun | - |
dc.contributor.author | Kim, Dong Wan | - |
dc.contributor.author | Kim, Tae You | - |
dc.contributor.author | Lee, Jong Seok | - |
dc.contributor.author | Heo, Dae Seog | - |
dc.contributor.author | Bang, Yung-Jue | - |
dc.contributor.author | Kim, Noe Kyeong | - |
dc.date.accessioned | 2010-01-07 | - |
dc.date.available | 2010-01-07 | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.created | 2020-04-08 | - |
dc.date.issued | 2005-12 | - |
dc.identifier.citation | Japanese Journal of Clinical Oncology, Vol.35 No.12, pp.720-726 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.other | 95316 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27180 | - |
dc.description.abstract | Background: Paclitaxel has shown promising activity in gastric cancer and has synergism with cisplatin. This study was performed to evaluate the efficacy and toxicity of low-dose paclitaxel (145 mg/m(2)) plus cisplatin chemotherapy in metastatic or relapsed gastric cancer. Methods: Chemotherapy-naive patients with metastatic or relapsed gastric cancer were enrolled. Paclitaxel 145 mg/m(2) was administered intravenously over 3 h, followed by cisplatin 60 mg/m(2) on Day 1 every 3 weeks in the outpatient setting. Results: Of 39 patients enrolled, 17 (44%) had partial responses. Twelve (31%) had stable disease and eight (21%) progressive disease. Two patients (5%) were not evaluable because of early drop-out. The median time to progression was 4.7 months and the median overall survival was 12.1 months. The most common hematologic toxicity was anemia (41%). Grade 3/4 neutropenia and thrombocytopenia developed in 14 and 3%, respectively. The most common non-hematologic toxicities were peripheral neuropathy (43%) and emesis (43%). Grade 3/4 non-hematologic toxicities included emesis (11%), peripheral neuropathy (3%), diarrhea (3%) and hepatotoxicity (3%). Conclusions: Low-dose paclitaxel and cisplatin chemotherapy was active and well-tolerated in chemotherapy-naive gastric cancer patients. This regimen seems to have comparable efficacy to previously reported higher-dose paclitaxel plus cisplatin-containing regimens and fewer toxicities. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | - |
dc.title | Phase II trial of low-dose paclitaxel and cisplatin in patients with advanced gastric cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 임석아 | - |
dc.identifier.doi | 10.1093/jjco/hyi198 | - |
dc.citation.journaltitle | Japanese Journal of Clinical Oncology | - |
dc.identifier.wosid | 000234436300005 | - |
dc.identifier.scopusid | 2-s2.0-30844442445 | - |
dc.citation.endpage | 726 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 720 | - |
dc.citation.volume | 35 | - |
dc.identifier.sci | 000234436300005 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Keun-Wook | - |
dc.contributor.affiliatedAuthor | Im, Seock Ah | - |
dc.contributor.affiliatedAuthor | Oh, Do Youn | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wan | - |
dc.contributor.affiliatedAuthor | Kim, Tae You | - |
dc.contributor.affiliatedAuthor | Lee, Jong Seok | - |
dc.contributor.affiliatedAuthor | Heo, Dae Seog | - |
dc.contributor.affiliatedAuthor | Bang, Yung-Jue | - |
dc.contributor.affiliatedAuthor | Kim, Noe Kyeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CONTINUOUS-INFUSION 5-FLUOROURACIL | - |
dc.subject.keywordPlus | COLONY-STIMULATING FACTOR | - |
dc.subject.keywordPlus | METASTATIC BREAST-CANCER | - |
dc.subject.keywordPlus | COMBINATION CHEMOTHERAPY | - |
dc.subject.keywordPlus | RANDOMIZED-TRIAL | - |
dc.subject.keywordPlus | SUPPORTIVE CARE | - |
dc.subject.keywordPlus | OVARIAN-CANCER | - |
dc.subject.keywordPlus | FOLINIC ACID | - |
dc.subject.keywordPlus | PLUS | - |
dc.subject.keywordPlus | DOXORUBICIN | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | cisplatin | - |
dc.subject.keywordAuthor | gastric cancer | - |
dc.subject.keywordAuthor | paclitaxel | - |
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