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Combinations containing amoxicillin-clavulanate and tetracycline are inappropriate for Helicobacter pylori eradication despite high in vitro susceptibility
DC Field | Value | Language |
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dc.contributor.author | Cheon, Jae Hee | - |
dc.contributor.author | Kim, Sang Gyun | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.date.accessioned | 2010-01-07T01:05:35Z | - |
dc.date.available | 2010-01-07T01:05:35Z | - |
dc.date.issued | 2006-08-25 | - |
dc.identifier.citation | J Gastroenterol Hepatol. 2006 Oct;21(10):1590-5. | en |
dc.identifier.issn | 0815-9319 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16928222 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27525 | - |
dc.description.abstract | BACKGROUND: The purpose of the present paper was to evaluate the efficacy and tolerability of amoxicillin-clavulanate and tetracycline-based quadruple therapy as an alternative second-line treatment for H. pylori infection. METHODS: The study subjects consisted of 54 patients infected with H. pylori, in whom initial triple therapy had failed. Subjects were randomized to receive the following 7-day therapies: (i) pantoprazole 40 mg b.i.d., tripotassium dicitrate bismuthate 300 mg q.i.d., amoxicillin-clavulanate 1000 mg b.i.d., and tetracycline 500 mg q.i.d. (PBAT); or (ii) pantoprazole 40 mg b.i.d., tripotassium dicitrate bismuthate 300 mg q.i.d., metronidazole 500 mg t.i.d., and tetracycline 500 mg q.i.d. (PBMT). Eradication rates based on antibiotic susceptibility, drug compliance and side-effect rates were evaluated and compared. RESULTS: The H. pylori eradication rates were 16.0%/17.4% with PBAT and 65.5%/70.4% with PBMT by intention-to-treat (P<0.001) and per-protocol analyses (P<0.001), respectively. In patients who received PBAT, the eradication rates were only 16.7% (2/12) for both amoxicillin and tetracycline-susceptible H. pylori strains. Drug compliance and side-effect rates were similar in the two groups. CONCLUSIONS: Despite high individual in vitro antimicrobial activity, amoxicillin-clavulanate and tetracycline-based quadruple therapy showed low eradication rates, which strongly suggests that it should not be considered as a therapeutic option for H. pylori eradication. | en |
dc.language.iso | en | - |
dc.publisher | Wiley-Blackwell | en |
dc.subject | 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use | en |
dc.subject | Amoxicillin-Potassium Clavulanate Combination/*contraindications | en |
dc.subject | Anti-Bacterial Agents/*contraindications | en |
dc.subject | Anti-Ulcer Agents/therapeutic use | en |
dc.subject | Biopsy | en |
dc.subject | Bismuth/therapeutic use | en |
dc.subject | Drug Therapy, Combination | en |
dc.subject | Endoscopy, Gastrointestinal | en |
dc.subject | Female | en |
dc.subject | Helicobacter Infections/*drug therapy/microbiology/pathology | en |
dc.subject | Helicobacter pylori/drug effects/*isolation & purification | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Metronidazole/therapeutic use | en |
dc.subject | Middle Aged | en |
dc.subject | Organometallic Compounds/therapeutic use | en |
dc.subject | Pyloric Antrum/*microbiology/pathology | en |
dc.subject | Stomach Ulcer/drug therapy/microbiology/pathology | en |
dc.subject | Tetracycline/*contraindications | en |
dc.subject | Treatment Failure | en |
dc.title | Combinations containing amoxicillin-clavulanate and tetracycline are inappropriate for Helicobacter pylori eradication despite high in vitro susceptibility | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 천재희 | - |
dc.contributor.AlternativeAuthor | 김상균 | - |
dc.contributor.AlternativeAuthor | 김정목 | - |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 이동호 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.1111/j.1440-1746.2006.04291.x | - |
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