Browse

Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice

DC Field Value Language
dc.contributor.authorChung, Yoon Hee-
dc.contributor.authorJoo, Kyeung Min-
dc.contributor.authorLim, Heon Chang-
dc.contributor.authorCho, Min Haeng-
dc.contributor.authorKim, Daejin-
dc.contributor.authorLee, Won Bok-
dc.contributor.authorCha, Choong Ik-
dc.date.accessioned2010-01-07T01:12:54Z-
dc.date.available2010-01-07T01:12:54Z-
dc.date.issued2005-06-28-
dc.identifier.citationBrain Res. 2005 Jul 19;1050(1-2):203-9.en
dc.identifier.issn0006-8993 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15978558-
dc.identifier.urihttp://hdl.handle.net/10371/27581-
dc.description.abstractIn the present study, we performed immunohistochemical studies to investigate the changes of phosphorylated extracellular signal-regulated kinases (pERK) in the central nervous system of SOD1(G93A) transgenic mice. In symptomatic transgenic mice, pERK-immunoreactive astrocytes were detected in the spinal cord, brainstem, central gray and cerebellar nuclei. In contrast to symptomatic mice, no pERK-immunoreactive astrocytes were observed in any brain region of wtSOD1 and presymptomatic mice, and the number and intensity of stained neurons were not different at the age of 8 weeks and 13 weeks. Interestingly, region-specific alterations in pERK immunoreactivity were observed in the hippocampal region and cerebellum. These results provide the first evidence that pERK-immunoreactive astrocytes were found in the CNS of SOD1(G93A) transgenic mice after clinical symptoms, showing a possible consequence of the pathological process of ALS. This study has also demonstrated that pERK increases in the hippocampus and cerebellum, suggesting a role of pERK in an abnormality of cognitive and/or motor function in ALS, respectively. However, the mechanisms underlying the increased immunoreactivity for pERK and the functional implications require elucidation.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAmyotrophic Lateral Sclerosis/*metabolism/pathologyen
dc.subjectAnimalsen
dc.subjectAstrocytes/*enzymology/pathologyen
dc.subjectCentral Nervous System/pathology/*physiopathologyen
dc.subjectExtracellular Signal-Regulated MAP Kinases/*metabolismen
dc.subjectImmunohistochemistryen
dc.subjectMiceen
dc.subjectMice, Inbred Strainsen
dc.subjectMice, Transgenicen
dc.subjectPhosphorylationen
dc.subjectSuperoxide Dismutase/*geneticsen
dc.titleImmunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic miceen
dc.typeArticleen
dc.contributor.AlternativeAuthor정윤희-
dc.contributor.AlternativeAuthor주경민-
dc.contributor.AlternativeAuthor임헌창-
dc.contributor.AlternativeAuthor조미행-
dc.contributor.AlternativeAuthor김대진-
dc.contributor.AlternativeAuthor이원복-
dc.contributor.AlternativeAuthor차충익-
dc.identifier.doi10.1016/j.brainres.2005.05.060-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse