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Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Yoon Hee | - |
dc.contributor.author | Joo, Kyeung Min | - |
dc.contributor.author | Lim, Heon Chang | - |
dc.contributor.author | Cho, Min Haeng | - |
dc.contributor.author | Kim, Daejin | - |
dc.contributor.author | Lee, Won Bok | - |
dc.contributor.author | Cha, Choong Ik | - |
dc.date.accessioned | 2010-01-07T01:12:54Z | - |
dc.date.available | 2010-01-07T01:12:54Z | - |
dc.date.issued | 2005-06-28 | - |
dc.identifier.citation | Brain Res. 2005 Jul 19;1050(1-2):203-9. | en |
dc.identifier.issn | 0006-8993 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15978558 | - |
dc.identifier.uri | https://hdl.handle.net/10371/27581 | - |
dc.description.abstract | In the present study, we performed immunohistochemical studies to investigate the changes of phosphorylated extracellular signal-regulated kinases (pERK) in the central nervous system of SOD1(G93A) transgenic mice. In symptomatic transgenic mice, pERK-immunoreactive astrocytes were detected in the spinal cord, brainstem, central gray and cerebellar nuclei. In contrast to symptomatic mice, no pERK-immunoreactive astrocytes were observed in any brain region of wtSOD1 and presymptomatic mice, and the number and intensity of stained neurons were not different at the age of 8 weeks and 13 weeks. Interestingly, region-specific alterations in pERK immunoreactivity were observed in the hippocampal region and cerebellum. These results provide the first evidence that pERK-immunoreactive astrocytes were found in the CNS of SOD1(G93A) transgenic mice after clinical symptoms, showing a possible consequence of the pathological process of ALS. This study has also demonstrated that pERK increases in the hippocampus and cerebellum, suggesting a role of pERK in an abnormality of cognitive and/or motor function in ALS, respectively. However, the mechanisms underlying the increased immunoreactivity for pERK and the functional implications require elucidation. | en |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.subject | Amyotrophic Lateral Sclerosis/*metabolism/pathology | en |
dc.subject | Animals | en |
dc.subject | Astrocytes/*enzymology/pathology | en |
dc.subject | Central Nervous System/pathology/*physiopathology | en |
dc.subject | Extracellular Signal-Regulated MAP Kinases/*metabolism | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred Strains | en |
dc.subject | Mice, Transgenic | en |
dc.subject | Phosphorylation | en |
dc.subject | Superoxide Dismutase/*genetics | en |
dc.title | Immunohistochemical study on the distribution of phosphorylated extracellular signal-regulated kinase (ERK) in the central nervous system of SOD1G93A transgenic mice | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정윤희 | - |
dc.contributor.AlternativeAuthor | 주경민 | - |
dc.contributor.AlternativeAuthor | 임헌창 | - |
dc.contributor.AlternativeAuthor | 조미행 | - |
dc.contributor.AlternativeAuthor | 김대진 | - |
dc.contributor.AlternativeAuthor | 이원복 | - |
dc.contributor.AlternativeAuthor | 차충익 | - |
dc.identifier.doi | 10.1016/j.brainres.2005.05.060 | - |
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