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Fractal dimension of cerebral cortical surface in schizophrenia and obsessive-compulsive disorder

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dc.contributor.authorHa, Tae Hyon-
dc.contributor.authorYoon, Uicheul-
dc.contributor.authorLee, Kyung Jin-
dc.contributor.authorShin, Yong Wook-
dc.contributor.authorLee, Jong-Min-
dc.contributor.authorKim, In Young-
dc.contributor.authorHa, Kyoo Seob-
dc.contributor.authorKim, Sun I-
dc.contributor.authorKwon, Jun Soo-
dc.date.accessioned2010-01-07T01:13:48Z-
dc.date.available2010-01-07T01:13:48Z-
dc.date.issued2005-05-17-
dc.identifier.citationNeurosci Lett. 2005 Aug 12-19;384(1-2):172-6.en
dc.identifier.issn0304-3940 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15893428-
dc.identifier.urihttp://hdl.handle.net/10371/27587-
dc.description.abstractSchizophrenia and obsessive-compulsive disorder (OCD) are assumed to be neurodevelopmental disorders. To examine the cortical patterns in the two disorders, three-dimensional fractal dimension (FD) of skeletonized cerebral cortical surface was estimated from magnetic resonance (MR) images of 50 patients with schizophrenia, 45 patients with OCD and 26 healthy normal controls. The schizophrenic group had a significantly smaller mean FD than OCD group, and the OCD group than normal controls. The FD revealed a significant interaction effect of group-by-hemisphere, and the FD asymmetry index distinguished the schizophrenic group from normal controls. In logistic regression models, the FD and CSF volume correctly classified 95.6% of the schizophrenics from the controls and 88.0% of the patients with OCD from the controls. In the control and schizophrenic groups, the FD was not associated with any of tissue volume measures. In the OCD group, however, the FD was significantly correlated with gray matter tissue volume and intracranial volume (ICV). The results of the present study suggest that three-dimensional FD of cortical surface may be a sensitive indicator for investigation of the structural brain abnormalities in mental disorders, especially those developmentally disturbed. Further studies to explore regional FD changes in mental disorders and clinical implications of the FD including diagnostic value should be performed in the future.en
dc.language.isoenen
dc.publisherElsevieren
dc.subjectAdulten
dc.subjectCerebral Cortex/*pathologyen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectImage Interpretation, Computer-Assisted/methodsen
dc.subjectImaging, Three-Dimensional/*methodsen
dc.subjectLogistic Modelsen
dc.subjectMagnetic Resonance Imaging/methodsen
dc.subjectMaleen
dc.subjectObsessive-Compulsive Disorder/cerebrospinal fluid/*pathologyen
dc.subjectSchizophrenia/cerebrospinal fluid/*pathologyen
dc.titleFractal dimension of cerebral cortical surface in schizophrenia and obsessive-compulsive disorderen
dc.typeArticleen
dc.contributor.AlternativeAuthor하태현-
dc.contributor.AlternativeAuthor윤의철-
dc.contributor.AlternativeAuthor이경진-
dc.contributor.AlternativeAuthor신용욱-
dc.contributor.AlternativeAuthor이종민-
dc.contributor.AlternativeAuthor김인영-
dc.contributor.AlternativeAuthor하규섭-
dc.contributor.AlternativeAuthor김선이-
dc.contributor.AlternativeAuthor권준수-
dc.identifier.doi10.1016/j.neulet.2005.04.078-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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