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Crystal structure of YrrB: a TPR protein with an unusual peptide-binding site

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dc.contributor.authorHan, Dohyun-
dc.contributor.authorOh, Jongkil-
dc.contributor.authorKim, Kyunggon-
dc.contributor.authorLim, Hyosun-
dc.contributor.authorKim, Youngsoo-
dc.date.accessioned2010-01-07T02:35:15Z-
dc.date.available2010-01-07T02:35:15Z-
dc.date.issued2007-07-13-
dc.identifier.citationBiochem Biophys Res Commun. 2007 Sep 7;360(4):784-90. Epub 2007 Jul 5.en
dc.identifier.issn0006-291X (Print)-
dc.identifier.urihttp://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4P48623-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=842ac4e3b02bc01a6a714438ee40fa46-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17624311-
dc.identifier.urihttps://hdl.handle.net/10371/27908-
dc.description.abstractYrrB is a hypothetical protein containing a tetratricopeptide repeat (TPR) domain from a Gram-positive bacterium, Bacillus subtilis. We determined YrrB structure in the C2 space group to 2.5A resolution, which is the first TPR structure of the Gram-positive bacterium B. subtilis. In contrast to other known TPR structures, the concave surface of the YrrB TPR domain is composed of the putative peptide-binding pocket lined with positively-charged residues. This unique charge distribution reveals that YrrB can interact with partner proteins via an unusual TPR-mediated interaction mode, compared to that of other TPR-containing structures. Functional annotation using genomics analysis suggested that YrrB may be an interacting mediator in the complex formation among RNA sulfuration components. No proteins containing a TPR domain have been identified in the biosynthesis of sulfur-containing biomolecules. Thus, YrrB could play a new role as a connecting module among those proteins in the conserved gene cluster for RNA sulfuration.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAmino Acid Sequenceen
dc.subjectBacillus subtilis/chemistryen
dc.subjectBacterial Proteins/*chemistry/metabolismen
dc.subjectBinding Sitesen
dc.subjectCrystallography, X-Rayen
dc.subjectMolecular Sequence Dataen
dc.subjectPeptides/*metabolismen
dc.subjectProtein Conformationen
dc.subjectRepetitive Sequences, Amino Aciden
dc.subjectSequence Homology, Amino Aciden
dc.titleCrystal structure of YrrB: a TPR protein with an unusual peptide-binding siteen
dc.typeArticleen
dc.contributor.AlternativeAuthor한도현-
dc.contributor.AlternativeAuthor오종길-
dc.contributor.AlternativeAuthor김경곤-
dc.contributor.AlternativeAuthor임효선-
dc.contributor.AlternativeAuthor김영수-
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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