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Characterization of two hepatitis B virus populations in a single Korean hepatocellular carcinoma patient with an HBeAg-negative serostatus: a novel X-Gene-deleted strain with inverted duplication sequences of upstream enhancer site II
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hong | - |
dc.contributor.author | Jee, Youngmee | - |
dc.contributor.author | Mun, Ho-Suk | - |
dc.contributor.author | Park, Ju-Hee | - |
dc.contributor.author | Yoon, Jung-Hwan | - |
dc.contributor.author | Kim, Yoon-Jun | - |
dc.contributor.author | Lee, Hyo-Suk | - |
dc.contributor.author | Hyun, Jin-Won | - |
dc.contributor.author | Hwang, Eung-Soo | - |
dc.contributor.author | Cha, Chang-Yong | - |
dc.contributor.author | Kook, Yoon-Hoh | - |
dc.contributor.author | Kim, Bum-Joon | - |
dc.date.accessioned | 2010-01-07T05:42:30Z | - |
dc.date.available | 2010-01-07T05:42:30Z | - |
dc.date.issued | 2007-06-16 | - |
dc.identifier.citation | Intervirology. 2007;50(4):273-80. Epub 2007 Jun 15. | en |
dc.identifier.issn | 1423-0100 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17570929 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28329 | - |
dc.description.abstract | OBJECTIVES: The aim of the study was to elucidate mutation patterns related to hepatocarcinogenesis in a Korean hepatocellular carcinoma (HCC) patient. METHODS: We analyzed full genome sequences of 6 hepatitis B virus (HBV) clones from an HCC patient. RESULTS: This patient harbored 2 HBV populations with genomes of different lengths (3,221 and 2,212 bp). In addition, we found 2 characteristic features not described so far in the full-genome sequence of deleted strains. First, 3 large deletion events (847, 144 and 48 bp) and a premature termination of the 182th codon of the surface antigen could lead to truncated or possibly nonfunctional forms of all HBV proteins. Second, these showed a novel mutation type not reported to date, which is a complex of an inverted duplication of 36-bp sequences containing an upstream enhancer site II (UEII), a remote insertion, and a large deletion event of the X region by homologous recombination. CONCLUSION: The fact that UEII is a binding site of liver-specific nuclear factor, which is expressed only in highly differentiated liver cells such as cancerous HepG2, strongly suggests a relationship between this novel mutation and hepatocarcinogenesis in this patient. | en |
dc.language.iso | en | en |
dc.publisher | Karger | en |
dc.subject | Carcinoma, Hepatocellular/*virology | en |
dc.subject | Enhancer Elements, Genetic/*genetics | en |
dc.subject | Evolution, Molecular | en |
dc.subject | Gene Deletion | en |
dc.subject | Gene Duplication | en |
dc.subject | Hepatitis B e Antigens/*blood | en |
dc.subject | Hepatitis B virus/*classification/genetics/isolation & | en |
dc.subject | purification/pathogenicity | en |
dc.subject | Humans | en |
dc.subject | Liver Neoplasms/*virology | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Molecular Sequence Data | en |
dc.subject | Recombination, Genetic | en |
dc.subject | Sequence Analysis, DNA | en |
dc.subject | Trans-Activators/*genetics | en |
dc.subject | Genome, Viral | - |
dc.title | Characterization of two hepatitis B virus populations in a single Korean hepatocellular carcinoma patient with an HBeAg-negative serostatus: a novel X-Gene-deleted strain with inverted duplication sequences of upstream enhancer site II | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김홍 | - |
dc.contributor.AlternativeAuthor | 지영미 | - |
dc.contributor.AlternativeAuthor | 문호숙 | - |
dc.contributor.AlternativeAuthor | 박주희 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 김윤준 | - |
dc.contributor.AlternativeAuthor | 이효석 | - |
dc.contributor.AlternativeAuthor | 현진원 | - |
dc.contributor.AlternativeAuthor | 황응수 | - |
dc.contributor.AlternativeAuthor | 차창용 | - |
dc.contributor.AlternativeAuthor | 김범준 | - |
dc.identifier.doi | 10.1159/000103915 | - |
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