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The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea
DC Field | Value | Language |
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dc.contributor.author | Kim, Nayoung | - |
dc.contributor.author | Cho, Sung-Il | - |
dc.contributor.author | Yim, Jeong-Yoon | - |
dc.contributor.author | Kim, Jung Mogg | - |
dc.contributor.author | Lee, Dong Ho | - |
dc.contributor.author | Park, Ji Hyun | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.date.accessioned | 2010-01-07T05:59:04Z | - |
dc.date.available | 2010-01-07T05:59:04Z | - |
dc.date.issued | 2006-04-04 | - |
dc.identifier.citation | Helicobacter. 2006 Apr;11(2):105-12. | en |
dc.identifier.issn | 1083-4389 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16579840 | - |
dc.identifier.uri | https://hdl.handle.net/10371/28369 | - |
dc.description.abstract | OBJECTIVE: To evaluate whether or not genetic polymorphism of IL-1B, IL-1RN, and TNF-Alpha is an important factor in the different expression of gastroduodenal diseases after Helicobacter pylori infection. METHODS: This study consisted of 1360 subjects: control, gastric cancer (GC, intestinal type, and diffuse type), benign gastric ulcer (BGU), duodenal ulcer, and first-degree gastric cancer relative (GCR). IL-1Beta-511 and TNF-A-308 biallelic polymorphism were genotyped by 5' nuclease polymerase chain reaction (PCR) assays, and PCR-restriction fragment length polymorphism (PCR-RFLP). IL-1RN penta-allelic variable number of tandem repeats was genotyped by PCR. RESULTS: There was no difference in the genetic polymorphism of IL-1Beta-511, IL-1RN and TNF-A in the patients with gastric cancer regardless of H. pylori positivity compared with control. However, the frequencies of IL-1B-511 C/T (OR: 0.5, 95% CI: 0.3-0.7) and T carrier (OR: 0.6, 95% CI: 0.4-0.8) were lower in the H. pylori-positive BGU patients. The IL-1RN 2/2 was higher (OR: 5.5, 95% CI: 1.1-28.5) in the H. pylori-positive GCR. There was no significance in the polymorphism of TNF-Alpha-308 regardless of H. pylori-induced gastroduodenal diseases. CONCLUSIONS: The IL-1Beta-511 T-carrier polymorphism has a negative effect on the development of H. pylori-positive BGU, and high frequency of IL-1RN 2/2 was found in the H. pylori-positive relatives of GC patients, which suggest that this genetic polymorphism could play some role in the H. pylori-induced gastroduodenal diseases in Korea. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Duodenal Ulcer/genetics/microbiology | en |
dc.subject | Female | en |
dc.subject | Gastrointestinal Diseases/*genetics/microbiology | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Genotype | en |
dc.subject | Helicobacter Infections/*complications | en |
dc.subject | Humans | en |
dc.subject | Interleukin-1/*genetics | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | Polymorphism, Restriction Fragment Length | en |
dc.subject | Stomach Neoplasms/genetics/microbiology | en |
dc.subject | Stomach Ulcer/genetics/microbiology | en |
dc.subject | Tumor Necrosis Factor-alpha/*genetics | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김나영 | - |
dc.contributor.AlternativeAuthor | 조성일 | - |
dc.contributor.AlternativeAuthor | 임정윤 | - |
dc.contributor.AlternativeAuthor | 김정목 | - |
dc.contributor.AlternativeAuthor | 이동호 | - |
dc.contributor.AlternativeAuthor | 박지현 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.1111/j.1523-5378.2006.00384.x | - |
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