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The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea

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dc.contributor.authorKim, Nayoung-
dc.contributor.authorCho, Sung-Il-
dc.contributor.authorYim, Jeong-Yoon-
dc.contributor.authorKim, Jung Mogg-
dc.contributor.authorLee, Dong Ho-
dc.contributor.authorPark, Ji Hyun-
dc.contributor.authorKim, Joo Sung-
dc.contributor.authorJung, Hyun Chae-
dc.contributor.authorSong, In Sung-
dc.date.accessioned2010-01-07T05:59:04Z-
dc.date.available2010-01-07T05:59:04Z-
dc.date.issued2006-04-04-
dc.identifier.citationHelicobacter. 2006 Apr;11(2):105-12.en
dc.identifier.issn1083-4389 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16579840-
dc.identifier.urihttps://hdl.handle.net/10371/28369-
dc.description.abstractOBJECTIVE: To evaluate whether or not genetic polymorphism of IL-1B, IL-1RN, and TNF-Alpha is an important factor in the different expression of gastroduodenal diseases after Helicobacter pylori infection. METHODS: This study consisted of 1360 subjects: control, gastric cancer (GC, intestinal type, and diffuse type), benign gastric ulcer (BGU), duodenal ulcer, and first-degree gastric cancer relative (GCR). IL-1Beta-511 and TNF-A-308 biallelic polymorphism were genotyped by 5' nuclease polymerase chain reaction (PCR) assays, and PCR-restriction fragment length polymorphism (PCR-RFLP). IL-1RN penta-allelic variable number of tandem repeats was genotyped by PCR. RESULTS: There was no difference in the genetic polymorphism of IL-1Beta-511, IL-1RN and TNF-A in the patients with gastric cancer regardless of H. pylori positivity compared with control. However, the frequencies of IL-1B-511 C/T (OR: 0.5, 95% CI: 0.3-0.7) and T carrier (OR: 0.6, 95% CI: 0.4-0.8) were lower in the H. pylori-positive BGU patients. The IL-1RN 2/2 was higher (OR: 5.5, 95% CI: 1.1-28.5) in the H. pylori-positive GCR. There was no significance in the polymorphism of TNF-Alpha-308 regardless of H. pylori-induced gastroduodenal diseases. CONCLUSIONS: The IL-1Beta-511 T-carrier polymorphism has a negative effect on the development of H. pylori-positive BGU, and high frequency of IL-1RN 2/2 was found in the H. pylori-positive relatives of GC patients, which suggest that this genetic polymorphism could play some role in the H. pylori-induced gastroduodenal diseases in Korea.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectDuodenal Ulcer/genetics/microbiologyen
dc.subjectFemaleen
dc.subjectGastrointestinal Diseases/*genetics/microbiologyen
dc.subjectGene Frequencyen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectHelicobacter Infections/*complicationsen
dc.subjectHumansen
dc.subjectInterleukin-1/*geneticsen
dc.subjectKoreaen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPolymerase Chain Reactionen
dc.subjectPolymorphism, Restriction Fragment Lengthen
dc.subjectStomach Neoplasms/genetics/microbiologyen
dc.subjectStomach Ulcer/genetics/microbiologyen
dc.subjectTumor Necrosis Factor-alpha/*geneticsen
dc.subjectPolymorphism, Genetic-
dc.titleThe effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Koreaen
dc.typeArticleen
dc.contributor.AlternativeAuthor김나영-
dc.contributor.AlternativeAuthor조성일-
dc.contributor.AlternativeAuthor임정윤-
dc.contributor.AlternativeAuthor김정목-
dc.contributor.AlternativeAuthor이동호-
dc.contributor.AlternativeAuthor박지현-
dc.contributor.AlternativeAuthor김주성-
dc.contributor.AlternativeAuthor정현채-
dc.contributor.AlternativeAuthor송인성-
dc.identifier.doi10.1111/j.1523-5378.2006.00384.x-
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