S-Space College of Medicine/School of Medicine (의과대학/대학원) Pediatrics (소아과학전공) Journal Papers (저널논문_소아과학전공)
Recombinant urate oxidase (Rasburicase) for the treatment of hyperuricemia in pediatric patients with hematologic malignancies: Results of a compassionate prospective multicenter study in Korea
- Shin, Hee Young; Kang, Hyoung Jin; Park, Eun Sil; Choi, Hyoung Soo; Ahn, Hyo Seop; Kim, Sun Young; Chung, Nak Gyun; Kim, Hack Ki; Kim, So Youn; Kook, Hoon; Hwang, Tai Ju; Lee, Kwang Chul; Lee, Sun Min; Lee, Kun Soo; Yoo, Keon Hee; Koo, Hong Hoe; Lee, Mee Jung; Seo, Jong Jin; Moon, Hyung Nam; Ghim, Thad; Lyu, Chuhl Joo; Lee, Won Sik; Choi, Yong Mook
- Issue Date
- Pediatr Blood Cancer. 2006 Apr;46(4):439-45.
- Adolescent; Child; Child, Preschool; Drug Administration Schedule; Female; Hematologic Neoplasms/*complications; Humans; Hyperuricemia/*complications/*drug therapy; Infant; Infant, Newborn; Korea/epidemiology; Male; Prospective Studies; Recombinant Proteins/administration & dosage/therapeutic use; Renal Dialysis; Treatment Outcome; Urate Oxidase/administration & dosage/adverse effects/*therapeutic use; Uric Acid/blood
- BACKGROUND: Hyperuricemia accompanying tumor lysis syndrome is a serious complication in neoplasia with rapid proliferation and destruction. To confirm the efficacy of recombinant urate oxidase (rasburicase) and its safety profile, a phase IV compassionate use prospective study was performed in Korean pediatric patients with hematologic malignancies. PROCEDURE: Rasburicase was administered at 0.2 mg/kg/day once daily for 3-5 days (twice daily allowed during the first 72 hr) by intravenous route for hyperuricemia (uric acid > 7.5 mg/dl). The study period was 5 weeks and consisted of a baseline assessment within 48 hr before the administration of rasburicase, 3-5 days of assessment during treatment and a follow-up assessment at 4 weeks after its final administration. RESULTS: The uric acid endpoint (< or =7.0 mg/dl) was reached in 97.3% (36/37) of the patients and uric acid levels were significantly reduced in all patients (P < 0.001). Drug related toxicities were mild and reversible without any grade 4 or serious adverse event associated with rasburicase. CONCLUSION: This study confirms that rasburicase is a safe and effective agent for the treatment of hyperuricemia associated with hematologic malignancies in pediatric patients.
- 1545-5009 (Print)
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