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Cerebral glucose metabolism in oculopalatal tremor

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dc.contributor.authorMoon, S Y-
dc.contributor.authorCho, S S-
dc.contributor.authorKim, Y K-
dc.contributor.authorKim, S E-
dc.contributor.authorKim, J H-
dc.contributor.authorKim, J S-
dc.date.accessioned2010-01-08T05:25:45Z-
dc.date.available2010-01-08T05:25:45Z-
dc.date.issued2007-11-17-
dc.identifier.citationEur J Neurol. 2008 Jan;15(1):42-9. Epub 2007 Nov 14.en
dc.identifier.issn1468-1331 (Electronic)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18005053-
dc.identifier.urihttps://hdl.handle.net/10371/28912-
dc.description.abstractNo study adopted the statistical parametric mapping (SPM) analyses of (18)F-fluorodeoxy glucose (FDG) PET in a large number of patients with oculopalatal tremor (OPT). To determine regional cerebral glucose metabolism in patients with OPT, nine patients with OPT underwent FDG-PET of the brain. Their glucose metabolism was compared with that of 50 normal controls (NC) by using SPM analyses. Three patients had bilateral and six showed unilateral pseudohypertrophic degeneration of the inferior olivary nucleus (ION) on MRI. Compared with NC, OPT patients did not show any metabolic derangement in the anterolateral medulla where the pseudohypertrophic ION locates. Instead, six patients with unilateral ION changes had hypometabolism in ipsilesional pontine tegmentum and hypermetabolism in contralesional thalamus. Their metabolic changes did not depend on the lateralization of ION changes. Our study failed to present any metabolic evidence for the role of ION in the generation of OPT. In part, the failure might originate from the different pathomechanism between OPT and pure palatal tremor or sensitivity/specificity issues of PET and SPM analyses. But, our results suggest that impaired cell groups of the paramedian tract and thalamic tremor cells may contribute to the generation of OPT.en
dc.language.isoenen
dc.publisherBlackwell Publishingen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBrain/metabolism/physiopathology/radionuclide imagingen
dc.subjectFluorodeoxyglucose F18/diagnostic useen
dc.subjectFunctional Laterality/physiologyen
dc.subjectGlucose/*metabolismen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyoclonus/*metabolism/physiopathology/radionuclide imagingen
dc.subjectNeural Pathways/metabolism/physiopathology/radionuclide imagingen
dc.subjectOlivary Nucleus/pathology/physiopathologyen
dc.subjectPons/metabolism/physiopathology/radionuclide imagingen
dc.subjectPositron-Emission Tomographyen
dc.subjectPredictive Value of Testsen
dc.subjectSensitivity and Specificityen
dc.subjectThalamus/metabolism/physiopathology/radionuclide imagingen
dc.subjectTremor/*metabolism/physiopathology/radionuclide imagingen
dc.titleCerebral glucose metabolism in oculopalatal tremoren
dc.typeArticleen
dc.identifier.doi10.1111/j.1468-1331.2007.01997.x-
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