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Asymmetrically altered integrity of cingulum bundle in posttraumatic stress disorder
Cited 76 time in
Web of Science
Cited 80 time in Scopus
- Authors
- Issue Date
- 2007-01-03
- Publisher
- Karger
- Citation
- Neuropsychobiology. 2006;54(2):120-5. Epub 2007 Jan 3.
- Keywords
- Adult ; Brain Mapping ; Case-Control Studies ; Chi-Square Distribution ; Diffusion Magnetic Resonance Imaging ; Female ; Gyrus Cinguli/*pathology ; Humans ; Magnetic Resonance Imaging, Cine ; Male ; Middle Aged ; Stress Disorders, Post-Traumatic/*pathology
- Abstract
- Previously, our group reported the altered white matter tract integrity of the left anterior cingulate in posttraumatic stress disorder (PTSD) in whole-brain exploration. Current study intended to explore whether the alteration was more prominent in any specific regions of the cingulum bundle. Diffusion tensor images of 21 PTSD subjects and 21 healthy comparison subjects were acquired. Eight isocubic regions of interest (ROIs), i.e. bilateral rostral, subgenual, dorsal, and upper cingulum bundle, were selected. Fractional anisotropy values in each ROI, which indicate the white matter tract integrity, were measured and compared between groups. Relative to comparison subjects, PTSD subjects had significantly smaller fractional anisotropy values in the left side of rostral, subgenual and dorsal cingulum bundle (26.7, 25.0, 22.2% decrease, respectively), but not in the right side ROIs. We report an asymmetrical alteration of the cingulum bundle in PTSD.
- ISSN
- 0302-282X (Print)
- Language
- English
- URI
- http://content.karger.com/produktedb/produkte.asp?typ=pdf&file=000098262
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17199097
https://hdl.handle.net/10371/28929
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