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Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women

Cited 38 time in Web of Science Cited 39 time in Scopus
Authors
Lee, Ji-Young; Choi, Ji-Yeob; Lee, Kyoung-Mu; Park, Sue Kyung; Han, So-Hee; Noh, Dong-Young; Ahn, Sei-Hyun; Kim, Dong-Hyun; Hong, Yun-Chul; Ha, Eunhee; Yoo, Keun-Young; Ambrosone, Christine B; Kang, Daehee
Issue Date
2007-12-28
Publisher
Elsevier
Citation
Clin Chim Acta. 2008 Mar;389(1-2):167-70. Epub 2007 Dec 14.
Keywords
Breast Neoplasms/*geneticsFemaleHumansHypoxia-Inducible Factor 1, alpha Subunit/*geneticsKoreaPolymorphism, Single NucleotideRisk Factors
Abstract
BACKGROUND: Hypoxia inducible factor 1 alpha (HIF-1A) is activated by low oxygen condition tension, a key regulator of the gene involved in the cellular response to hypoxia. Tumors exhibiting extensive hypoxia are more aggressive than tumors oxygenized better. METHODS: To evaluate the potential role of the polymorphisms of HIF-1A in the etiology of breast cancer, histologically confirmed incident breast cancer cases (n=1599) and control subjects (n=1536) were recruited. RESULTS: Two selected SNPs (Ex15+197C>T and P582S) were not associated with overall breast cancer risk (TT vs. CC: OR=0.9, 95% CI=0.6-1.5, Ser/Ser vs. Pro/Pro: OR=5.5, 95% CI=0.7-45.4, respectively). However, when stratified analyses were performed, significant associations were observed between Ser/Ser genotype at codon 582 and breast cancer risk among women with larger tumor size (>2 cm) (OR=10.1, 95% CI=1.1-91.1) or without lymph node involvement (OR=9.3, 95% CI=1.1-79.4), although confidence intervals were wide. CONCLUSIONS: Our findings support the hypothesis that the HIF-1Alpha P582S variant may confer susceptibility to subgroups of breast cancer in Korean women. However, further study is warranted due to low statistical power caused by very low minor allele frequencies.
ISSN
0009-8981 (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T57-4RBYD3C-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ef953babd10409ea4170c33bb90bcbde

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18160046

http://hdl.handle.net/10371/29051
DOI
https://doi.org/10.1016/j.cca.2007.12.005
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College of Medicine/School of Medicine (의과대학/대학원)Program in Cancer Biology (협동과정-종양생물학전공)Journal Papers (저널논문_협동과정-종양생물학전공)
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