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Frontal glucose hypometabolism in abstinent methamphetamine users

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dc.contributor.authorKim, Seog Ju-
dc.contributor.authorLyoo, In Kyoon-
dc.contributor.authorHwang, Jaeuk-
dc.contributor.authorSung, Young Hoon-
dc.contributor.authorLee, Ho Young-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorJeong, Do-Un-
dc.contributor.authorRenshaw, Perry F-
dc.date.accessioned2010-01-08T08:21:45Z-
dc.date.available2010-01-08T08:21:45Z-
dc.date.issued2005-02-24-
dc.identifier.citationNeuropsychopharmacology. 2005 Jul;30(7):1383-91.en
dc.identifier.issn0893-133X (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15726115-
dc.identifier.urihttps://hdl.handle.net/10371/29055-
dc.description.abstractChanges in relative regional cerebral glucose metabolism (rCMRglc) and their potential gender differences in abstinent methamphetamine (MA) users were explored. Relative rCMRglc, as measured by (18)F-fluorodeoxyglucose positron emission tomography, and frontal executive functions, as assessed by Wisconsin card sorting test (WCST), were compared between 35 abstinent MA users and 21 healthy comparison subjects. In addition, male and female MA users and their gender-matched comparison subjects were compared to investigate potential gender differences. MA users had lower rCMRglc levels in the right superior frontal white matter and more perseveration and nonperseveration errors in the WCST, relative to healthy comparison subjects. Relative rCMRglc in the frontal white matter correlated with number of errors in the WCST in MA users. In the subanalysis for gender differences, lower rCMRglc in the frontal white matter and more errors in the WCST were found only in male MA users, not in female MA users, relative to their gender-matched comparison subjects. The current findings suggest that MA use causes persistent hypometabolism in the frontal white matter and impairment in frontal executive function. Our findings also suggest that the neurotoxic effect of MA on frontal lobes of the brain might be more prominent in men than in women.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.subjectAdulten
dc.subjectAmphetamine-Related Disorders/*metabolism/physiopathology/radionuclideen
dc.subjectimagingen
dc.subjectBrain Mappingen
dc.subjectCase-Control Studiesen
dc.subjectDemographyen
dc.subjectFemaleen
dc.subjectFluorodeoxyglucose F18/pharmacokineticsen
dc.subjectFrontal Lobe/*metabolism/physiopathology/radionuclide imagingen
dc.subjectGlucose/*metabolismen
dc.subjectHumansen
dc.subjectImage Processing, Computer-Assisted/methodsen
dc.subjectLinear Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNeuropsychological Tests/statistics & numerical dataen
dc.subjectPositron-Emission Tomography/methodsen
dc.subjectSex Characteristicsen
dc.titleFrontal glucose hypometabolism in abstinent methamphetamine usersen
dc.typeArticleen
dc.contributor.AlternativeAuthor김석주-
dc.contributor.AlternativeAuthor류인균-
dc.contributor.AlternativeAuthor황재욱-
dc.contributor.AlternativeAuthor성영훈-
dc.contributor.AlternativeAuthor이호영-
dc.contributor.AlternativeAuthor이동수-
dc.contributor.AlternativeAuthor정도운-
dc.identifier.doi10.1038/sj.npp.1300699-
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