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Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis

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dc.contributor.authorLee, Sang Hyub-
dc.contributor.authorRyu, Ji Kon-
dc.contributor.authorJeong, Ji Bong-
dc.contributor.authorLee, Kyeung-Yeup-
dc.contributor.authorWoo, Sang Myung-
dc.contributor.authorPark, Joo Kyung-
dc.contributor.authorYoo, Ji Won-
dc.contributor.authorKim, Yong-Tae-
dc.contributor.authorYoon, Yong Bum-
dc.date.accessioned2010-01-08T08:22:34Z-
dc.date.available2010-01-08T08:22:34Z-
dc.date.issued2007-10-18-
dc.identifier.citationDig Dis Sci. 2008 Jun;53(6):1721-7.en
dc.identifier.issn0163-2116 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17940904-
dc.identifier.urihttps://hdl.handle.net/10371/29057-
dc.description.abstractAlcoholic chronic pancreatitis (ACP) develops in only a small number of alcoholics. Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis. However, their role in pathogenesis of ACP has not been investigated. A genetic association study for susceptibility and severity was performed on 79 male Korean ACP patients and 82 male controls. MCP-1 and HSP70-2 genotypes were determined using a fluorescence polarization detection method. The genotypes and G allele frequencies were no different in patients and controls. However, MCP-1 G allele had an effect on the development of severe ACP, when its frequency was compared in mild to moderate and severe ACP (29.6 vs. 56.0%, P = 0.02). The MCP-1 and HSP70-2 polymorphisms do not play a major role in the development of ACP in Koreans. However, MCP-1 polymorphism may be associated with the severity of ACP.en
dc.language.isoenen
dc.publisherSpringer Verlagen
dc.subjectChemokine CCL2/*geneticsen
dc.subjectChi-Square Distributionen
dc.subjectGene Frequencyen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenotypeen
dc.subjectHSP70 Heat-Shock Proteins/*geneticsen
dc.subjectHumansen
dc.subjectKorea/epidemiologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectPancreatitis, Alcoholic/epidemiology/*geneticsen
dc.subjectPancreatitis, Chronic/epidemiology/*geneticsen
dc.subjectPrevalenceen
dc.subjectProspective Studiesen
dc.subjectPolymorphism, Genetic-
dc.titlePolymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitisen
dc.typeArticleen
dc.contributor.AlternativeAuthor이상협-
dc.contributor.AlternativeAuthor류지곤-
dc.contributor.AlternativeAuthor정지봉-
dc.contributor.AlternativeAuthor이경엽-
dc.contributor.AlternativeAuthor우상명-
dc.contributor.AlternativeAuthor박주경-
dc.contributor.AlternativeAuthor유지원-
dc.contributor.AlternativeAuthor김용태-
dc.contributor.AlternativeAuthor윤용범-
dc.identifier.doi10.1007/s10620-007-0049-1-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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