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Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis
Cited 6 time in
Web of Science
Cited 8 time in Scopus
- Authors
- Issue Date
- 2007-10-18
- Publisher
- Springer Verlag
- Citation
- Dig Dis Sci. 2008 Jun;53(6):1721-7.
- Keywords
- Chemokine CCL2/*genetics ; Chi-Square Distribution ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; HSP70 Heat-Shock Proteins/*genetics ; Humans ; Korea/epidemiology ; Male ; Middle Aged ; Pancreatitis, Alcoholic/epidemiology/*genetics ; Pancreatitis, Chronic/epidemiology/*genetics ; Prevalence ; Prospective Studies ; Polymorphism, Genetic
- Abstract
- Alcoholic chronic pancreatitis (ACP) develops in only a small number of alcoholics. Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis. However, their role in pathogenesis of ACP has not been investigated. A genetic association study for susceptibility and severity was performed on 79 male Korean ACP patients and 82 male controls. MCP-1 and HSP70-2 genotypes were determined using a fluorescence polarization detection method. The genotypes and G allele frequencies were no different in patients and controls. However, MCP-1 G allele had an effect on the development of severe ACP, when its frequency was compared in mild to moderate and severe ACP (29.6 vs. 56.0%, P = 0.02). The MCP-1 and HSP70-2 polymorphisms do not play a major role in the development of ACP in Koreans. However, MCP-1 polymorphism may be associated with the severity of ACP.
- ISSN
- 0163-2116 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17940904
https://hdl.handle.net/10371/29057
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