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Arsenic trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60

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dc.contributor.authorHan, Seong-Su-
dc.contributor.authorKim, Kihyun-
dc.contributor.authorHahm, Eun-Ryeong-
dc.contributor.authorPark, Chan H-
dc.contributor.authorKimler, Bruce F-
dc.contributor.authorLee, Sook J-
dc.contributor.authorLee, Se-Hoon-
dc.contributor.authorKim, Won S-
dc.contributor.authorJung, Chul Won-
dc.contributor.authorPark, Keunchil-
dc.contributor.authorKim, Jingook-
dc.contributor.authorYoon, Sung-Soo-
dc.contributor.authorLee, Je-Ho-
dc.contributor.authorPark, Seyeon-
dc.date.accessioned2010-01-08T08:26:01Z-
dc.date.available2010-01-08T08:26:01Z-
dc.date.issued2004-11-18-
dc.identifier.citationJ Cell Biochem. 2005 Mar 1;94(4):695-707.en
dc.identifier.issn0730-2312 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15547942-
dc.identifier.urihttps://hdl.handle.net/10371/29067-
dc.description.abstractIt has been proposed that eukaryotic nuclear factor nuclear factor kappa-B (NF-kappaB) and cyclooxygenase-2 (COX-2) are implicated in the pathogenesis of many human diseases including cancer. Arsenic has been widely used in medicine in Oriental countries. Recent studies have shown that arsenic trioxide (As(2)O(3)) could induce in vitro growth inhibition and apoptosis of malignant lymphocytes, and myeloma cells. However, the molecular mechanisms by which As(2)O(3) initiates cellular signaling toward cell death are still unclear. In the present study, the effects of As(2)O(3) on NF-kappaB and COX-2 expression in HL-60 cells were investigated. As(2)O(3) suppressed DNA-binding activity of NF-kappaB composed of p65/p50 heterodimer through preventing the degradation of IkappaB-alpha and the nuclear translocation of p65 subsequently as well as interrupting the binding of NF-kappaB with their consensus sequences. Inhibitory effect of As(2)O(3) on NF-kappaB DNA activity was dependent upon intracellular glutathione (GSH) and H(2)O(2) level, but not superoxide anion. Futhermore, we found that As(2)O(3) also downregulated the expression of COX-2, which has NF-kappaB binding site on its promoter through repressing the NF-kappaB DNA-binding activity.en
dc.language.isoen-
dc.publisherWiley-Blackwellen
dc.subjectApoptosis/drug effectsen
dc.subjectArsenicals/*pharmacologyen
dc.subjectCyclooxygenase 2en
dc.subjectDNA/metabolismen
dc.subjectEnzyme Activation/drug effectsen
dc.subjectGene Expression Regulation, Enzymologic/drug effectsen
dc.subjectGene Expression Regulation, Neoplastic/*drug effectsen
dc.subjectGlutathione/metabolismen
dc.subjectHL-60 Cellsen
dc.subjectHumansen
dc.subjectHydrogen Peroxide/metabolismen
dc.subjectI-kappa B Kinaseen
dc.subjectLeukemia, Myeloid, Acute/enzymology/genetics/metabolismen
dc.subjectMembrane Proteinsen
dc.subjectNF-kappa B/chemistry/*metabolismen
dc.subjectOxides/*pharmacologyen
dc.subjectProstaglandin-Endoperoxide Synthases/*metabolismen
dc.subjectProtein Binding/drug effectsen
dc.subjectProtein Subunits/chemistry/metabolismen
dc.subjectProtein Transport/drug effectsen
dc.subjectProtein-Serine-Threonine Kinases/metabolismen
dc.titleArsenic trioxide represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60en
dc.typeArticleen
dc.contributor.AlternativeAuthor한성수-
dc.contributor.AlternativeAuthor김기현-
dc.contributor.AlternativeAuthor함은령-
dc.contributor.AlternativeAuthor이세훈-
dc.contributor.AlternativeAuthor정철원-
dc.contributor.AlternativeAuthor박근칠-
dc.contributor.AlternativeAuthor김진국-
dc.contributor.AlternativeAuthor윤성수-
dc.contributor.AlternativeAuthor이제호-
dc.contributor.AlternativeAuthor박세연-
dc.identifier.doi10.1002/jcb.20337-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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