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Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance

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dc.contributor.authorKim, Yon Su-
dc.contributor.authorYang, Seung Hee-
dc.contributor.authorKang, Hee Gyung-
dc.contributor.authorSeong, Eun Young-
dc.contributor.authorLee, Se Han-
dc.contributor.authorGao, Wenda-
dc.contributor.authorKenny, James-
dc.contributor.authorZheng, Xin Xiao-
dc.contributor.authorStrom, Terry B-
dc.date.accessioned2010-01-08T08:33:28Z-
dc.date.available2010-01-08T08:33:28Z-
dc.date.issued2006-10-28-
dc.identifier.citationInt Immunol. 2006 Dec;18(12):1771-7. Epub 2006 Oct 26.en
dc.identifier.issn0953-8178 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17068105-
dc.identifier.urihttps://hdl.handle.net/10371/29081-
dc.description.abstractDendritic cells (DCs) are pivotal antigen-presenting cells and serve a unique role in initiating immunity. To test the hypothesis that pre-immunization of recipient with certain DC subsets of donor origin can influence graft outcome, we have studied the effects of immunization with allogeneic CD4(+)CD8(-)CD11c(+) dendritic cell (CD4(+)DC) and CD4(-)CD8(+)CD11c(+) dendritic cell (CD8(+)DC) on the allograft response. Although both immature CD4(+)DC and CD8(+)DC subsets from DBA/2 were able to prime naive allogeneic C57BL/6 (B6) T cells in mixed lymphocyte reaction (MLR), CD8(+)DC exerted more vigorous alloimmune responses than CD4(+)DC did. Also, CD4(+)DC-driven allogeneic T cell response was attenuated more significantly by anti-CD154 mAb than CD8(+)DC-driven response. Consistent with the MLR results, combined pre-treatment with CD4(+)DC, but not CD8(+)DC, plus anti-CD154 mAb produced donor strain-specific long-term graft survival and induced tolerance while treatment with CD8(+)DC plus anti-CD154 mAb created minimal prolongation of allograft survival in a pancreas islet transplant model (DBA/2-->B6). The beneficial effects exerted by CD4(+)DC and anti-CD154 mAb pre-treatment were correlated with T(h)1 to T(h)2 immune deviation and with the amplified donor-specific suppressive capacity by recipient CD4(+)CD25(+) T cells. These findings highlight the capacity of CD4(+)DC to modulate alloimmune responses, and suggest therapeutic approaches for the induction of donor-specific tolerance.en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.subjectAnimalsen
dc.subjectAntigens, CD11c/metabolismen
dc.subjectAntigens, CD4/metabolismen
dc.subjectAntigens, CD8/metabolismen
dc.subjectDendritic Cells/*cytology/transplantationen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Inbred C57BLen
dc.subjectMice, Inbred DBAen
dc.subjectSpecies Specificityen
dc.subjectGraft Survival/physiology-
dc.subjectIslets of Langerhans Transplantation-
dc.subjectTissue Donors/classification-
dc.subjectTransplantation Tolerance-
dc.subjectTransplantation, Homologous-
dc.titleDistinctive role of donor strain immature dendritic cells in the creation of allograft toleranceen
dc.typeArticleen
dc.contributor.AlternativeAuthor김연수-
dc.contributor.AlternativeAuthor양승희-
dc.contributor.AlternativeAuthor강희경-
dc.contributor.AlternativeAuthor성은영-
dc.contributor.AlternativeAuthor이세한-
dc.identifier.doi10.1093/intimm/dxl111-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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