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Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Yang, Seung Hee | - |
dc.contributor.author | Kang, Hee Gyung | - |
dc.contributor.author | Seong, Eun Young | - |
dc.contributor.author | Lee, Se Han | - |
dc.contributor.author | Gao, Wenda | - |
dc.contributor.author | Kenny, James | - |
dc.contributor.author | Zheng, Xin Xiao | - |
dc.contributor.author | Strom, Terry B | - |
dc.date.accessioned | 2010-01-08T08:33:28Z | - |
dc.date.available | 2010-01-08T08:33:28Z | - |
dc.date.issued | 2006-10-28 | - |
dc.identifier.citation | Int Immunol. 2006 Dec;18(12):1771-7. Epub 2006 Oct 26. | en |
dc.identifier.issn | 0953-8178 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17068105 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29081 | - |
dc.description.abstract | Dendritic cells (DCs) are pivotal antigen-presenting cells and serve a unique role in initiating immunity. To test the hypothesis that pre-immunization of recipient with certain DC subsets of donor origin can influence graft outcome, we have studied the effects of immunization with allogeneic CD4(+)CD8(-)CD11c(+) dendritic cell (CD4(+)DC) and CD4(-)CD8(+)CD11c(+) dendritic cell (CD8(+)DC) on the allograft response. Although both immature CD4(+)DC and CD8(+)DC subsets from DBA/2 were able to prime naive allogeneic C57BL/6 (B6) T cells in mixed lymphocyte reaction (MLR), CD8(+)DC exerted more vigorous alloimmune responses than CD4(+)DC did. Also, CD4(+)DC-driven allogeneic T cell response was attenuated more significantly by anti-CD154 mAb than CD8(+)DC-driven response. Consistent with the MLR results, combined pre-treatment with CD4(+)DC, but not CD8(+)DC, plus anti-CD154 mAb produced donor strain-specific long-term graft survival and induced tolerance while treatment with CD8(+)DC plus anti-CD154 mAb created minimal prolongation of allograft survival in a pancreas islet transplant model (DBA/2-->B6). The beneficial effects exerted by CD4(+)DC and anti-CD154 mAb pre-treatment were correlated with T(h)1 to T(h)2 immune deviation and with the amplified donor-specific suppressive capacity by recipient CD4(+)CD25(+) T cells. These findings highlight the capacity of CD4(+)DC to modulate alloimmune responses, and suggest therapeutic approaches for the induction of donor-specific tolerance. | en |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | en |
dc.subject | Animals | en |
dc.subject | Antigens, CD11c/metabolism | en |
dc.subject | Antigens, CD4/metabolism | en |
dc.subject | Antigens, CD8/metabolism | en |
dc.subject | Dendritic Cells/*cytology/transplantation | en |
dc.subject | Humans | en |
dc.subject | Mice | en |
dc.subject | Mice, Inbred C57BL | en |
dc.subject | Mice, Inbred DBA | en |
dc.subject | Species Specificity | en |
dc.subject | Graft Survival/physiology | - |
dc.subject | Islets of Langerhans Transplantation | - |
dc.subject | Tissue Donors/classification | - |
dc.subject | Transplantation Tolerance | - |
dc.subject | Transplantation, Homologous | - |
dc.title | Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 양승희 | - |
dc.contributor.AlternativeAuthor | 강희경 | - |
dc.contributor.AlternativeAuthor | 성은영 | - |
dc.contributor.AlternativeAuthor | 이세한 | - |
dc.identifier.doi | 10.1093/intimm/dxl111 | - |
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