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Differential expression of vitreous proteins in proliferative diabetic retinopathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sang Jin | - |
dc.contributor.author | Kim, Sangmi | - |
dc.contributor.author | Park, Jungeun | - |
dc.contributor.author | Lee, Hong Kyu | - |
dc.contributor.author | Park, Kyong Soo | - |
dc.contributor.author | Yu, Hyeong Gon | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.date.accessioned | 2010-01-11T01:15:43Z | - |
dc.date.available | 2010-01-11T01:15:43Z | - |
dc.date.issued | 2006-03-15 | - |
dc.identifier.citation | Curr Eye Res. 2006 Mar;31(3):231-40. | en |
dc.identifier.issn | 0271-3683 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16531280 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29261 | - |
dc.description.abstract | PURPOSE: To identify vitreous proteins that were differentially expressed in patients suffering from proliferative diabetic retinopathy with active neovascularization. METHODS: The vitreous samples of 15 active proliferative diabetic retinopathy patients were analyzed by two-dimensional gel electrophoresis and mass spectrometry, and the results were compared with those from age-matched patients with macular hole. RESULTS: Twenty-five protein spots were identified in the two-dimensional gel electrophoresis gels. Eight proteins (pigmented epithelium derived factor, serine protease inhibitor, apolipoprotein A-IV precursor, prostaglandin-H2 D-isomerase, a(1)-antitrypsin precursor, ankyrin repeat domain 15 protein, alpha2-HS-glycoprotein, and beta V spectrin) in the 25 spots were expressed significantly differently between the macular hole and proliferative diabetic retinopathy patients (p value < 0.05). Five proteins were upregulated in the proliferative diabetic retinopathy patients, and three were downregulated (p value < 0.05). CONCLUSIONS: We constructed vitreous protein profiles for proliferative diabetic retinopathy patients and identified eight candidate proteins believed to be involved in the pathogenesis of proliferative diabetic retinopathy. | en |
dc.language.iso | en | en |
dc.publisher | Taylor & Francis | en |
dc.subject | Aged | en |
dc.subject | Biological Markers/metabolism | en |
dc.subject | Diabetic Retinopathy/complications/*metabolism/surgery | en |
dc.subject | Electrophoresis, Gel, Two-Dimensional | en |
dc.subject | Eye Proteins/*metabolism | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Mass Spectrometry | en |
dc.subject | Middle Aged | en |
dc.subject | Retinal Neovascularization/complications/metabolism/surgery | en |
dc.subject | Vitrectomy | en |
dc.subject | Vitreous Body/*metabolism | en |
dc.title | Differential expression of vitreous proteins in proliferative diabetic retinopathy | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김상진 | - |
dc.contributor.AlternativeAuthor | 김상미 | - |
dc.contributor.AlternativeAuthor | 박정은 | - |
dc.contributor.AlternativeAuthor | 이홍규 | - |
dc.contributor.AlternativeAuthor | 박경수 | - |
dc.contributor.AlternativeAuthor | 유형곤 | - |
dc.contributor.AlternativeAuthor | 김영수 | - |
dc.identifier.doi | 10.1080/02713680600557030 | - |
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