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Improved survival in patients with recurrent Wilms tumor: the experience of the Seoul National University Children's Hospital

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Authors
Park, Eun Sil; Kang, Hyoung Jin; Shin, Hee Young; Ahn, Hyo Seop
Issue Date
2006-06-17
Publisher
Korean Academy of Medical Science
Citation
J Korean Med Sci. 2006 Jun;21(3):436-40.
Keywords
Antineoplastic Combined Chemotherapy Protocols/*therapeutic useChildChild, PreschoolDisease-Free SurvivalFemaleHumansInfantKoreaMale*Peripheral Blood Stem Cell Transplantation*RecurrenceTime FactorsTreatment OutcomeWilms Tumor/*mortality/*pathology
Abstract
The survival in cases with relapsed Wilms tumor is dismal. Recently, however the introduction of new therapeutic agents and experimental strategies has improved the survival. We analysed the survival of patients with relapsed Wilms tumor according to the treatment period. During the early period 1983-1993, patients who had received two drugs were treated with doxorubicin and the others were treated with cisplatin and etoposide, whereas during the late period 1994-2004, patients were treated with combinations of cyclophosphamide/etoposide and carboplatin/etoposide. During the early period, 8 of 57 experienced relapse, and 8 of 41 relapsed during the late period. Only 2 patients treated during the early period survived in complete response (CR), whereas during the late period, 5 patients remained alive in CR, and 3 of those received high-dose chemotherapy (HDC) with autologous peripheral stem cell rescue (SCR). The estimated 5 yr event-free survival rate was 37.5% in the entire study group, 50% for patients in the late period, and 25% for patients in the early period (p=0.38). The survival in patients with relapsed Wilms tumor dramatically improved during the late period and HDC with SCR was one of the effective salvage strategies.
ISSN
1011-8934 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16778385

http://hdl.handle.net/10371/29283
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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