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Disease-specific proteins from rheumatoid arthritis patients

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dc.contributor.authorKim, Choong Won-
dc.contributor.authorCho, Eun Hye-
dc.contributor.authorLee, Yun Jong-
dc.contributor.authorKim, Yoon Hee-
dc.contributor.authorHah, Young Sool-
dc.contributor.authorKim, Deok Ryong-
dc.date.accessioned2010-01-11T07:08:40Z-
dc.date.available2010-01-11T07:08:40Z-
dc.date.issued2006-06-17-
dc.identifier.citationJ Korean Med Sci. 2006 Jun;21(3):478-84.en
dc.identifier.issn1011-8934 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16778393-
dc.identifier.urihttps://hdl.handle.net/10371/29359-
dc.description.abstractRheumatoid arthritis (RA) is a chronic inflammatory disease that mainly destroys cartilages or bones at the joints. This inflammatory disorder is initiated by self-attack using own immune system, but the detail of pathological mechanism is unclear. Features of autoantigens leading to autoimmune disease are also under veil although several candidates including type II collagen have been suggested to play a role in pathogenesis. In this report, we tried to identify proteins responding to antibodies purified from RA patients and screen proteins up-regulated or down-regulated in RA using proteomic approach. Fibronectin, semaphorin 7A precursor, growth factor binding protein 7 (GRB7), and immunoglobulin mu chain were specifically associated with antibodies isolated from RA synovial fluids. In addition, some metabolic proteins such as adipocyte fatty acid binding protein, galectin-1 and apolipoprotein A1 precursor were overexpressed in RA synovium. Also, expression of peroxiredoxin 2 was up-regulated in RA. On the contrary, expression of vimentin was severely suppressed in RA synoviocytes. Such findings might give some insights into understanding of pathological mechanism in RA.en
dc.language.isoenen
dc.publisherKorean Academy of Medical Scienceen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectArthritis, Rheumatoid/*metabolismen
dc.subjectAutoantigens/metabolismen
dc.subjectCollagen Type II/biosynthesisen
dc.subjectFemaleen
dc.subject*Gene Expression Regulationen
dc.subjectHumansen
dc.subject*Inflammationen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProteomics/methodsen
dc.subjectSepharose/chemistryen
dc.subjectSynovial Fluid/metabolismen
dc.titleDisease-specific proteins from rheumatoid arthritis patientsen
dc.typeArticleen
dc.contributor.AlternativeAuthor김충원-
dc.contributor.AlternativeAuthor조은혜-
dc.contributor.AlternativeAuthor이윤종-
dc.contributor.AlternativeAuthor김윤희-
dc.contributor.AlternativeAuthor하영술-
dc.contributor.AlternativeAuthor김덕룡-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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