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Dinucleotide repeat polymorphism in intron II of human Toll-like receptor 2 gene and susceptibility to rheumatoid arthritis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, E Y | - |
dc.contributor.author | Yim, J-J | - |
dc.contributor.author | Lee, H S | - |
dc.contributor.author | Lee, Y J | - |
dc.contributor.author | Lee, E B | - |
dc.contributor.author | Song, Y W | - |
dc.date.accessioned | 2010-01-11T07:15:41Z | - |
dc.date.available | 2010-01-11T07:15:41Z | - |
dc.date.issued | 2006-05-23 | - |
dc.identifier.citation | Int J Immunogenet. 2006 Jun;33(3):211-5. | en |
dc.identifier.issn | 1744-3121 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16712654 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29373 | - |
dc.description.abstract | Human Toll-like receptors (TLRs) participate in innate immune response and signal the activation of adaptive immunity. The presence of a functional intronic polymorphism consisting of guanine-thymine repeats in TLR2 gene was recently reported. Here, we investigated a dinucleotide repeat polymorphism in intron II of TLR2 in Korean patients with rheumatoid arthritis (RA). The numbers of guanine-thymine [(GT)(n)] repeats in intron II of the TLR 2 gene were counted in 183 patients with RA and in 148 healthy controls, using the gene scanning technique. We classified alleles into two subclasses for further analysis, 12-16 GT repeats (S allele) and 17-28 repeats (L allele). By subgroup analysis, we also examined whether the S allele is associated with the presence of shared epitope (SE), rheumatoid factor (RF), joint erosion and extra-articular complications. S-allele frequency was significantly increased in patients with RA than in healthy controls [30.3% vs. 23.0%, P = 0.03, or 1.46, 95% confidence interval (CI) 1.03-2.07], and genotypes containing S alleles were more frequent in patients with RA than in healthy controls (54.4% vs. 46.5%. P = 0.04, or 1.57, 95% CI 1.01-2.42). A skewed S-allele distribution was not found to be related to the presence of SE. Subgroup analysis showed no genotypic or allele frequency differences between patients with/without RF, joint erosion, or extra-articular complications. Genotype containing shorter GT repeats in intron II of the TLR2 gene may confer susceptibility to RA in Koreans. | en |
dc.language.iso | en | en |
dc.publisher | Wiley-Blackwell | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Alleles | en |
dc.subject | Arthritis, Rheumatoid/*genetics/immunology | en |
dc.subject | Asian Continental Ancestry Group | en |
dc.subject | Dinucleotide Repeats/*genetics/immunology | en |
dc.subject | Epitopes/genetics/immunology | en |
dc.subject | Female | en |
dc.subject | Gene Frequency | en |
dc.subject | Genetic Predisposition to Disease/*genetics | en |
dc.subject | Humans | en |
dc.subject | Introns/*genetics/immunology | en |
dc.subject | Korea | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Rheumatoid Factor/immunology | en |
dc.subject | Toll-Like Receptor 2/*genetics/immunology | en |
dc.subject | Polymorphism, Genetic | - |
dc.title | Dinucleotide repeat polymorphism in intron II of human Toll-like receptor 2 gene and susceptibility to rheumatoid arthritis | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1744-313X.2006.00599.x | - |
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