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Stage-specific expression of two neighboring Crlz1 and IgJ genes during B cell development is regulated by their chromatin accessibility and histone acetylation

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dc.contributor.authorLim, Jung-Hyun-
dc.contributor.authorCho, Sun-Jung-
dc.contributor.authorPark, Sung-Kyun-
dc.contributor.authorKim, Jiyoung-
dc.contributor.authorCho, Daeho-
dc.contributor.authorLee, Wang Jae-
dc.contributor.authorKang, Chang-Joong-
dc.date.accessioned2010-01-12T01:28:01Z-
dc.date.available2010-01-12T01:28:01Z-
dc.date.issued2006-10-04-
dc.identifier.citationJ Immunol. 2006 Oct 15;177(8):5420-9.en
dc.identifier.issn0022-1767 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17015728-
dc.identifier.urihttps://hdl.handle.net/10371/29492-
dc.description.abstractThe IgJ gene is expressed in the plasma cell stage. However, its neighboring charged amino acid-rich leucine zipper 1 (Crlz1) gene, which is mapped 30 kb upstream of the IgJ gene in mice, is shown to be expressed in the pre-B cell stage. These stage-specific expressions of two neighboring genes are found to be regulated by their chromatin accessibility and acetylation. Hypersensitive site 1 on the IgJ promoter is opened in the plasma cells, whereas hypersensitive sites 9/10 on the Crlz1 promoter are opened in the pre-B cells. Furthermore, H3 and H4 histones toward the chromatin of the Crlz1 gene are found to be hyperacetylated, especially on H3, in the pre-B cells, whereas those toward the chromatin of the IgJ gene are found to be hyperacetylated in the plasma cells. Consistently, the hyperacetylation of H3 and H4 toward the chromatin of the IgJ gene but not the Crlz1 gene is induced by an IL-2 treatment of BCL1, which is a model cell line for studying the terminal differentiation of B cells.en
dc.language.isoenen
dc.publisherAmerican Association of Immunologistsen
dc.subjectAcetylationen
dc.subjectAnimalsen
dc.subjectB-Lymphocytes/*cytology/immunologyen
dc.subjectCell Lineen
dc.subjectChromatin/*metabolismen
dc.subjectDNA-Binding Proteins/*geneticsen
dc.subjectGene Expression Regulation/*immunologyen
dc.subjectHistones/*metabolismen
dc.subjectImmunoglobulin J-Chains/*geneticsen
dc.subjectMiceen
dc.subjectNerve Tissue Proteins/*geneticsen
dc.subjectPlasma Cells/cytology/immunologyen
dc.subjectPromoter Regions, Geneticen
dc.subjectTranscription Factors/*geneticsen
dc.titleStage-specific expression of two neighboring Crlz1 and IgJ genes during B cell development is regulated by their chromatin accessibility and histone acetylationen
dc.typeArticleen
dc.contributor.AlternativeAuthor임정현-
dc.contributor.AlternativeAuthor조선정-
dc.contributor.AlternativeAuthor박성균-
dc.contributor.AlternativeAuthor김지영-
dc.contributor.AlternativeAuthor조대호-
dc.contributor.AlternativeAuthor이왕재-
dc.contributor.AlternativeAuthor강창중-
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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