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Chronic atrioventricular nodal vagal stimulation: first evidence for long-term ventricular rate control in canine atrial fibrillation model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhang, Youhua | - |
dc.contributor.author | Yamada, Hirotsugu | - |
dc.contributor.author | Bibevski, Steve | - |
dc.contributor.author | Zhuang, Shaowei | - |
dc.contributor.author | Mowrey, Kent A | - |
dc.contributor.author | Wallick, Don W | - |
dc.contributor.author | Oh, Seil | - |
dc.contributor.author | Mazgalev, Todor N | - |
dc.date.accessioned | 2010-01-12T01:48:26Z | - |
dc.date.available | 2010-01-12T01:48:26Z | - |
dc.date.issued | 2005-11-02 | - |
dc.identifier.citation | Circulation. 2005 Nov 8;112(19):2904-11. Epub 2005 Oct 31. | en |
dc.identifier.issn | 1524-4539 (Electronic) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16260638 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29524 | - |
dc.description.abstract | BACKGROUND: We have previously demonstrated that selective atrioventricular nodal (AVN) vagal stimulation (AVN-VS) can be used to control ventricular rate during atrial fibrillation (AF) in acute experiments. However, it is not known whether this approach could provide a long-term treatment in conscious animals. Thus, this study reports the first observations on the long-term efficacy and safety of this novel approach to control ventricular rate during AF in chronically instrumented dogs. METHODS AND RESULTS: In 18 dogs, custom-made bipolar patch electrodes were sutured to the epicardial AVN fat pad for delivery of selective AVN-VS by a subcutaneously implanted nerve stimulator (pulse width 100 micros or 1 ms, frequency 20 or 160 Hz, amplitude 6 to 10 V). Fast-rate right atrial pacing (600 bpm) was used to induce and maintain AF. ECG, blood pressure, and body temperature were monitored telemetrically. One week after the induction of AF, AVN-VS was delivered and maintained for at least 5 weeks. It was found that AVN-VS had a consistent effect on ventricular rate slowing (on average 45+/-13 bpm) over the entire period of observation. Echocardiography showed improvement of cardiac indices with ventricular rate slowing. AVN-VS was well tolerated by the animals, causing no signs of distress or discomfort. CONCLUSIONS: Beneficial long-term ventricular rate slowing during AF can be achieved by implantation of a nerve stimulator attached to the epicardial AVN fat pad. This novel concept is an attractive alternative to other methods of rate control and may be applicable in a selected group of patients. | en |
dc.language.iso | en | - |
dc.publisher | American Heart Association | en |
dc.subject | Animals | en |
dc.subject | Atrial Fibrillation/*therapy | en |
dc.subject | Atrioventricular Node/*innervation | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Dogs | en |
dc.subject | Electric Stimulation Therapy/*methods | en |
dc.subject | Telemetry | en |
dc.subject | Vagus Nerve/*physiology | en |
dc.subject | Ventricular Function | - |
dc.title | Chronic atrioventricular nodal vagal stimulation: first evidence for long-term ventricular rate control in canine atrial fibrillation model | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 오세일 | - |
dc.identifier.doi | 10.1161/CIRCULATIONAHA.105.568832 | - |
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