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Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children

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dc.contributor.authorLee, J.-
dc.contributor.authorOh, Y.-
dc.contributor.authorKim, C.-
dc.contributor.authorKim, S.-
dc.contributor.authorPark, H.-
dc.contributor.authorKim, H.-
dc.date.accessioned2010-01-12T02:06:18Z-
dc.date.available2010-01-12T02:06:18Z-
dc.date.issued2006-09-22-
dc.identifier.citationActa Anaesthesiol Scand. 2006 Oct;50(9):1161-4.en
dc.identifier.issn0001-5172 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16987347-
dc.identifier.urihttps://hdl.handle.net/10371/29566-
dc.description.abstractBACKGROUND: Airway irritation is a major drawback of desflurane anesthesia. This study was designed to evaluate the effect of intravenous fentanyl given before thiopental induction on airway irritation caused by a stepwise increase in desflurane in children. METHODS: Eighty children (2-8 years) were enrolled in a randomized, double-blind study. Forty received saline and 40 received 2 microg/kg of fentanyl intravenously; this was followed by thiopental sodium 5 mg/kg in both groups. Patients were assistant-ventilated with desflurane 1%, which was then increased by 1% every six breaths up to 10%. During this period, cough, secretion, excitation and apnea were graded and the desflurane concentration at which airway irritation symptoms first occurred was recorded. The results were analyzed using Pearson's chi-squared test. RESULTS: The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2.5% vs. 42.5%; secretion, 27.5% vs. 82.5%; excitation, 10% vs. 82.5%; apnea, 20% vs. 65%; P < 0.05). The mean expired desflurane concentration at which the first airway irritation symptom occurred was greater with fentanyl than with saline (7.3% vs. 5.5%, P < 0.05). CONCLUSIONS: Intravenous fentanyl in children reduces airway complications caused by desflurane.en
dc.language.isoenen
dc.publisherMunksgaarden
dc.subjectAnalgesics, Opioid/adverse effects/*therapeutic useen
dc.subjectAnesthesia, General/*adverse effectsen
dc.subjectAnesthetics, Inhalation/*adverse effectsen
dc.subjectApnea/chemically induced/drug therapyen
dc.subjectBlood Pressure/physiologyen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectCough/chemically induced/drug therapyen
dc.subjectDouble-Blind Methoden
dc.subjectElectrocardiographyen
dc.subjectFemaleen
dc.subjectFentanyl/adverse effects/*therapeutic useen
dc.subjectHeart Rate/physiologyen
dc.subjectHumansen
dc.subjectHypnotics and Sedatives/*adverse effectsen
dc.subjectInjections, Intravenousen
dc.subjectIsoflurane/adverse effects/*analogs & derivativesen
dc.subjectMaleen
dc.subjectMucus/secretionen
dc.subjectThiopental/*adverse effectsen
dc.subjectIrritants-
dc.titleFentanyl reduces desflurane-induced airway irritability following thiopental administration in childrenen
dc.typeArticleen
dc.identifier.doi10.1111/j.1399-6576.2006.01134.x-
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