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Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, J. | - |
dc.contributor.author | Oh, Y. | - |
dc.contributor.author | Kim, C. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Park, H. | - |
dc.contributor.author | Kim, H. | - |
dc.date.accessioned | 2010-01-12T02:06:18Z | - |
dc.date.available | 2010-01-12T02:06:18Z | - |
dc.date.issued | 2006-09-22 | - |
dc.identifier.citation | Acta Anaesthesiol Scand. 2006 Oct;50(9):1161-4. | en |
dc.identifier.issn | 0001-5172 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16987347 | - |
dc.identifier.uri | https://hdl.handle.net/10371/29566 | - |
dc.description.abstract | BACKGROUND: Airway irritation is a major drawback of desflurane anesthesia. This study was designed to evaluate the effect of intravenous fentanyl given before thiopental induction on airway irritation caused by a stepwise increase in desflurane in children. METHODS: Eighty children (2-8 years) were enrolled in a randomized, double-blind study. Forty received saline and 40 received 2 microg/kg of fentanyl intravenously; this was followed by thiopental sodium 5 mg/kg in both groups. Patients were assistant-ventilated with desflurane 1%, which was then increased by 1% every six breaths up to 10%. During this period, cough, secretion, excitation and apnea were graded and the desflurane concentration at which airway irritation symptoms first occurred was recorded. The results were analyzed using Pearson's chi-squared test. RESULTS: The incidence of typical airway irritation events was lower with fentanyl than with saline (cough, 2.5% vs. 42.5%; secretion, 27.5% vs. 82.5%; excitation, 10% vs. 82.5%; apnea, 20% vs. 65%; P < 0.05). The mean expired desflurane concentration at which the first airway irritation symptom occurred was greater with fentanyl than with saline (7.3% vs. 5.5%, P < 0.05). CONCLUSIONS: Intravenous fentanyl in children reduces airway complications caused by desflurane. | en |
dc.language.iso | en | en |
dc.publisher | Munksgaard | en |
dc.subject | Analgesics, Opioid/adverse effects/*therapeutic use | en |
dc.subject | Anesthesia, General/*adverse effects | en |
dc.subject | Anesthetics, Inhalation/*adverse effects | en |
dc.subject | Apnea/chemically induced/drug therapy | en |
dc.subject | Blood Pressure/physiology | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Cough/chemically induced/drug therapy | en |
dc.subject | Double-Blind Method | en |
dc.subject | Electrocardiography | en |
dc.subject | Female | en |
dc.subject | Fentanyl/adverse effects/*therapeutic use | en |
dc.subject | Heart Rate/physiology | en |
dc.subject | Humans | en |
dc.subject | Hypnotics and Sedatives/*adverse effects | en |
dc.subject | Injections, Intravenous | en |
dc.subject | Isoflurane/adverse effects/*analogs & derivatives | en |
dc.subject | Male | en |
dc.subject | Mucus/secretion | en |
dc.subject | Thiopental/*adverse effects | en |
dc.subject | Irritants | - |
dc.title | Fentanyl reduces desflurane-induced airway irritability following thiopental administration in children | en |
dc.type | Article | en |
dc.identifier.doi | 10.1111/j.1399-6576.2006.01134.x | - |
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